banner medline tsn
 
Медико-биологический
информационный портал
для специалистов
 
Medline.ru

СОДЕРЖАНИЕ ЖУРНАЛА:
Физико-химическая биология

Клиническая медицина

Профилактическая медицина

Медико-биологические науки


АРХИВ:

Фундаментальные исследования

Организация здравохраниения

История медицины и биологии



Последние публикации

Поиск публикаций

Articles

Архив :  2000 г.  2001 г.  2002 г. 
               2003 г.  2004 г.  2005 г. 
               2006 г.  2007 г.  2008 г. 
               2009 г.  2010 г.  2011 г. 
               2012 г.  2013 г.  2014 г. 
               2015 г.  2016 г.  2017 г. 
               2018 г.  2019 г.  2020 г.  2021 г.  2022 г.  2023 г. 

Редакционная информация:
        Опубликовать статью
        Наша статистика


 РЕДАКЦИЯ:
Главный редактор

Заместители главного редактора

Члены редколлегии
Специализированные редколлегии


 УЧРЕДИТЕЛИ:
Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН"

ФГБУН "Институт токсикологии" ФМБА России




Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

Свидетельство о регистрации электронного периодического издания ЭЛ № ФС 77-37726 от 13.10.2009
Выдано - Роскомнадзор

ISSN 1999-6314

Российская поисковая система
Искать: 


«
Vol. 21, Art. 59 (pp. 718-729)    |    2020       
»

General patterns of synergistic interaction of heavy metals with hyperthermia or ionizing radiation
1A. Tsyb Medical Radiological Research Center - branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation,
Obninsk, 249031, Kaluga region, Russia
2Federal State Budgetary Institution Scientific Research Center for Radiology of the Ministry of Health of Russia, Kaluga Region, Obninsk, e-mail: marya.tolkaeva@yandex.ru



Brief summary

The work is devoted to the study of the synergistic effect display after the simultaneous interaction of heavy metal salts and hyperthermia. It is shown that synergistic interaction is observed only in a certain range of acting temperatures and concentrations of heavy metals, which can be different for various conditions of combined treatments. In this case, the optimum temperature or concentration of the heavy metal is recorded at which the greatest synergistic interaction is observed. The dependence of synergism on the concentration of heavy metals was revealed. It was shown that the lower this concentration, the lower the greatest synergistic effect recorded. These data can be considered as an indication of the potential significance of synergistic interactions at low concentrations of harmful substances that are important for environmental problems. A qualitative interpretation of the results obtained is discussed.


Key words

synergism, hyperthermia, heavy metals, synergistic enhancement ratio, drug concentration.





(The article in PDF format. For preview need Adobe Acrobat Reader)



Open article in new window

Reference list

1. Arskii U.M., Danilov-Danilyan V.I., Zalihanov M.I. i dr. Ekologicheskie problemi: chto proishodit, kto vinovat i chto delat? M.: MNEPY, 1997. 330 c.


2. VOZ. Yltrafioletovoe izlychenie. Jeneva, 1995. - 394 s.


3. Vronskii V.A. Prikladnaya ekologiya. Rostov-na-Dony: Feniks, 1996. 512 s.


4. Danilov-Danilyan V.I., Gorshkov V.G., Arskii U.M. i dr. Okryjaushaya sreda mejdy proshlim i bydyshim: mir i Rossiya (opit ekologo-ekonomicheskogo analiza). M.: VINITI, 1994. 134 s.


5. Dodina L.G. Naryshenie zdorovya naseleniya i mehanizmi adaptacii v ysloviyah vozdeistviya antropogennih faktorov maloi intensivnosti. Avtoref. dokt. diss. Sankt-Peterbyrg, 1998.


6. Doklad 30 MKRE. Kolichestvennie zakonomernosti i dozimetriya v radiobiologii. M.: Energoatmizdat, 1984. 104 s.


7. Evstratova E.S., Petin V.G. Biofizicheskaya interpretaciya zavisimosti sinergizma ot intensivnosti primenyaemih agentov // Biofizika. 2018. T. 63. Vip. 6. S. 1186-1194.


8. Petin V.G., Jyrakovskaya G.P., Komarova L.N. Radiobiologicheskie osnovi sinergicheskih vzaimodeistviya v biosfere. M.: GEOS, 2012. 219 s.


9. Feller V. Vvedenie v teoriu veroyatnostei i ee prilojeniya. M.: Mir, 1967. 765 s.


10. Shybik V.M., Kolotvin V.A., Liberman A.N. i dr. Vliyanie sochetannogo SVCh i rentgenovskogo oblycheniya na immynologicheskyu reaktivnost // Gigienicheskaya ocenka faktorov radiacionnoi i neradiacionnoi prirodi i ih kombinacii / Pod red. A.N. Libermana. - L.: Minzdrav RSFSR, 1976. - S. 42-44.


11. Archer V.E. Enhancement of lung cancer by cigarette smoking in uranium and other miners // Carcinogenesis.1985. V. 8, 1. P. 23-37.


12. Evstratova E.S., Petin V.G., Zhurakovskaya G.P. Synergistic effects and their potential significance for the influence of natural intensities of environmental factors on cell growth // Synergy. 2018.V. 6, 1. P. 1-8.


13. Pershagen F., Akerblom G., Axelson O. et al. Residental radon exposure and lung cancer in Sweden // New Engl. J. Medicine. 1994. V. 330. P. 159-164.


14. Petin V.G., Kim J.K. Synergistic Interaction and Cell Responses to Environmental Factors. N.Y.: Nova Publishers, 2016. 337 p.





References


1. Arskij Ju.M., Danilov-Daniljan V.I., Zalihanov M.I. and etc. Environmental problems: what happens, who is to blame and what to do? M : MNEPU, 1997.330 p. [In Russian]


2. WHO. Ultraviolet radiation. Geneva, 1995.- 394 p. [In Russian]


3. Vronskij V.A. Applied Ecology. Rostov-on-Don: Phoenix, 1996.512 s. [In Russian]


4. Danilov-Danil'jan V.I., Gorshkov V.G., Arskij Ju.M. and etc. The environment between the past and the future: the world and Russia (experience in environmental and economic analysis). M .: VINITI, 1994.134 p. [In Russian]


5. Dodina L.G. Violation of the health of the population and adaptation mechanisms under the influence of anthropogenic factors of low intensity. Abstract. Doct. diss. St. Petersburg, 1998. [In Russian]


6. Report 30 ICRU. Quantitative patterns and dosimetry in radiobiology. M .: Energoatmizdat, 1984. 104 p. [In Russian]


7. Evstratova E.S., Petin V.G. Biophysical interpretation of the dependence of synergism on the intensity of the agents used // Biophysics. 2018.Vol. 63. Issue. 6, p. 1186-1194. [In Russian]


8. Petin V.G., Zhurakovskaya G.P., Komarova L.N. Radiobiological Basis of Synergistic Interaction in Biosphere. M.: GEOS., 2012. 218 p. [In Russian]


9. Feller V. Introduction to probability theory and its applications. M .: Mir, 1967.765 p. [In Russian]


10. Shubik V.M., Kolotvin V.A., Liberman A.N. et al. The effect of combined microwave and x-ray irradiation on immunological reactivity // Hygienic assessment of factors of radiation and non-radiation nature and their combinations / Ed. A.N. Liberman. - L .: Ministry of Health of the RSFSR, 1976. - p. 42-44. [In Russian]


11. Archer V.E. Enhancement of lung cancer by cigarette smoking in uranium and other miners // Carcinogenesis.1985. V. 8, 1. P. 23-37.


12. Evstratova E.S., Petin V.G., Zhurakovskaya G.P. Synergistic effects and their potential significance for the influence of natural intensities of environmental factors on cell growth // Synergy. 2018.V. 6, 1. P. 1-8.


13. Pershagen F., Akerblom G., Axelson O. et al. Residental radon exposure and lung cancer in Sweden // New Engl. J. Medicine. 1994. V. 330. P. 159-164.


14. Petin V.G., Kim J.K. Synergistic Interaction and Cell Responses to Environmental Factors. N.Y.: Nova Publishers, 2016. 337 p.





Журнал основан 16 ноября 2000г.
Выдано Министерством РФ по делам печати, телерадиовещания и средств массовых коммуникаций
(c) Перепечатка материалов сайта Medline.Ru возможна только с письменного разрешения редакции

Размещение рекламы

Rambler's Top100