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Vol. 27, Art. 46 (pp. 1140-1155) | 2026
Endocrine regulation under conditions of extreme changes in the light regime
Batotsyrenova E.G.1,2*, Shkutina I.V2, Kuzmina N.V. 2, Tinus A.M.2, Timofeyev S.V2, Kolbasova T.A.1, Shchepetkova K.M.2, Kashuro V.A.2,3,4
1The Federal State-Financed Institution Golikov Research Clinical Center of Toxicology under the Federal Medical-Biological Agency, Saint Petersburg, Russian Federation 2Federal State Budgetary Institution of Higher Professional Education «St. Petersburg State Pediatric Medical University» of the Ministry of Healthcare of the Russian Federation, Saint Petersburg, Russia 3Federal State Budgetary Educational Institution of Higher Education "Saint-Petersburg State University", Saint Petersburg, Russia 3The Herzen State Pedagogical University of Russia Saint Petersburg, Russian Federation
Brief summary
Introduction. Irregular work schedules, excessive artificial light at night, and inconsistent sleep patterns are frequently associated with the disruption of circadian rhythms. This desynchronization of biological rhythms alters the secretion of hormones and neurotransmitters—including thyroid hormones, which regulate energy metabolism (such as food intake, thermogenesis, and the metabolism of carbohydrates and lipids). Such dysregulation increases the risk of developing metabolic syndrome. The aim of the study. The aim of this study was to investigate how extreme changes in light exposure affect the levels of thyroid hormones and the sex hormone testosterone, analyzed through the lens of stress-activating and stress-limiting systems, in order to identify potential pathways leading to metabolic disturbances. Materials and Methods. The study was conducted on outbred white rats (*Rattus norvegicus*) of both sexes during the autumn season. In the light-deprivation model, animals were kept without any external light source. Conversely, in the dark-deprivation model, animals were exposed to constant lighting with an intensity of 500 lux. Both light and dark deprivation were maintained for 10 days, after which the animals were returned to their original housing conditions. Ten days later, blood samples were collected for analysis. Plasma concentrations of total T3 (TT3), total T4 (TT4), and testosterone were measured using an Immulite 2000 chemiluminescent analyzer. Results. After 10 days of extreme changes to the lighting regimen, the concentration of the hormone T3 (triiodothyronine) in the blood plasma showed a statistically significant change: levels decreased compared to the control group under both constant light (darkness deprivation) and constant darkness (light deprivation). A decrease in T4 (thyroxine/tetraiodothyronine) concentration in the blood plasma was observed only in the darkness-deprivation group, though this change was not statistically significant. Conversely, serum testosterone levels increased in the darkness-deprivation group compared to the control. Ten days after the experimental animals were returned to their original living conditions, the following hormonal values were recorded in the blood plasma: a statistically significant increase in both T3 and T4 concentrations in the light-deprivation group, and a statistically significant increase in testosterone levels in the darkness-deprivation group, relative to control values. Conclusion. Alterations to the lighting regimen lead to changes in the formation of the melatonin concentration peak and in the secretion of pituitary tropic hormones, which contributes to an improved tolerance for stress. Key words desynchronosis, triiodothyronine, tetraiodothyronine, testosterone (The article in PDF format. For preview need Adobe Acrobat Reader)  Open article in new window
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