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Vol. 27, Art. 31 (pp. 710-745)    |    2026       

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Prospects for the use of β-d-glucans in patients with severe inflammatory disease. literature review and announcement of own research

Fursova E.N., Yazenok A.V., Popov A.V., Ananenko V.A.
Federal State Budgetary Educational Institution of Higher Education "Military Medical Academy named after S.M. Kirov" Ministry of Defense of the Russian Federation

Brief summary

The history of the use of mushroom extracts in medicine dates back centuries, however, scientific evidence of their immunomodulatory properties is primarily related to the development of beta-D-glucans began only in the second half of the 20th century. Modern studies demonstrate the significant potential of β-D-glucans as adjuvants capable of minimizing side effects and enhancing the effectiveness of the main treatment. The aim of the study. The purpose of the article is to comprehensively analyze the accumulated historical and modern experience in order to re-evaluate the role of β-D-glucans and identify clear, scientifically sound prospects for their integration into combination therapy regimens, especially in the context of managing post-therapeutic complications and improving long-term treatment outcomes. Material and methods. Over 60 literature sources were analyzed, including foreign and domestic articles, patents, and a number of experiments were initiated using the β-D-glucans based dietary supplement within the framework of the PRIORITY 2030 program. Results. In the course of studying the literature, a number of properties of β D-glucans were noted, the key of which is a positive effect on the immune status: increased activity of NK cells, granulocytes and T-lymphocyte levels. This body of data serves as a powerful argument that β-D-glucans have serious potential for correcting immune disorders after other severe conditions such as pneumonia. Conclusion. After the acute phase of severe pneumonia is relieved, the key task is to overcome post-infectious immunosuppression and restore adequate immune surveillance to prevent relapses and secondary infections, which can be provided by complex therapy, which can include β D-glucans, as a more physiological and safe way to restore cytokine balance after the cytokine storm characteristic of severe pneumonia.


Key words

β-D-glucans; pneumonia; complex therapy; recovery period

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