|
Медико-биологический
информационный портал
|
 |
для специалистов |
|
|
|
Vol. 25, Art. 1 (pp. 1-15) | 2024
Combined treatment of patients with locally advanced outlet obstructive gastric cancer: protocol of a pilot clinical trial
Svechkova A.A., Zakharenko A.A.
Federal State Budgetary Educational Institution of Higher Education ?Academician I.P. Pavlov First St. Petersburg State Medical University? of the Ministry of Healthcare of Russian Federation, 197022, Russian Federation, St. Petersburg, st. Lev Tolstoy, 6-8
Brief summary
Gastric cancer is still a global health problem as a malignant neoplasm of high aggressiveness due to its heterogeneous nature. Despite the development of methods for early diagnosis and treatment, the overall 5-year survival rate for gastric cancer is 32.4%. Among patients admitted for treatment, 40% have a complicated course of the disease. In the structure of complications of gastric cancer, stenoses occur in 36.1% of cases, especially when the tumor is located in the cardioesophageal junction or in the outlet section of the stomach. Tumor obstruction of the stomach manifests itself already in the late stages of the disease and negatively affects the quality of life of patients due to the symptoms associated with it. Conducting a full-fledged neoadjuvant stage of treatment against the background of subcompensated gastric stenosis is often impossible due to increasing nutritional insufficiency, water and electrolyte disorders. Modern domestic and foreign clinical guidelines do not offer a unified standardized approach for gastric tumor obstruction in patients with a locally advanced process. Endoscopic photodynamic therapy seems to be a promising treatment method of potentially operable patients with malignant gastric outlet obstruction in combination with neoadjuvant chemotherapy. An objective assessment of the use of endoscopic photodynamic therapy in the combined treatment of locally advanced gastric cancer complicated by subcompensated tumor stenosis requires a clinical trial. Key words gastric cancer; endoscopic photodynamic therapy; malignant gastric outlet obstruction; combined treatment (The article in PDF format. For preview need Adobe Acrobat Reader)  Open article in new window
Reference list 1. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. // CA Cancer J Clin. 2021;71(3):209-249. https://doi.org/10.3322/caac.21660 2. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. // CA Cancer J Clin 2018. Nov; 68(6):394-424. https://doi.org/10.3322/caac.21492 3. Machlowska J, Baj J, Sitarz M, Maciejewski R, Sitarz R. Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies. // Int J Mol Sci. 2020 Jun 4;21(11):4012. https://doi.org/10.3390/ijms21114012 4. Xia JY, Aadam AA. Advances in screening and detection of gastric cancer. // J Surg Oncol. 2022 Jun;125(7):1104-1109. https://doi.org/10.1002/jso.26844 5. Afanasev S.G., Avgystinovich A.V., Tyzikov S.A., Pak A.V., Volkov M.U., Savelev I.N., Frolova I.G. Rezyltati kombinirovannih operacii pri mestno-rasprostranennom rake jelydka. Onkologiya. // Jyrnal im. P.A. Gercena. 2013;2:12-15 [Afanasiev S. G., Avgustinovich A. V., Tuzikov S. A., Pak A. Vplkov, M. Y. Results of combined operations in locally advanced gastric cancer. Oncology. // Journal them. P.A. Herzen. 2013;2:12-15. (In Russ).]. 6. Papanikolaou IS, Siersema PD. Gastric Outlet Obstruction: Current Status and Future Directions. // Gut Liver. 2022 Sep 15;16(5):667-675. doi: 10.5009/gnl210327. Epub 2022 Mar 22. PMID:35314520; PMCID: PMC9474481. https://doi.org/10.5009/gnl210327 7. Tendler DA. Malignant gastric outlet obstruction: bridging another divide. // Am J Gastroenterol. 2002;97:4-6. https://doi.org/10.1016/S0002-9270(01)03953-3 8. Luo T, Du Y, Duan J, Liang C, Chen G, Jiang K, Chen Y, Chen Y. Development and Validation of a Scoring System Based on 9 Glycolysis-Related Genes for Prognosis Prediction in Gastric Cancer. // Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820971670. https://doi.org/10.1177/1533033820971670 9. Sherbakov A.M. Primenenie endoskopicheskoi argon-plazmennoi koagylyacii v palliativnom lechenii recidiva raka jelydka pri anastomozah pishevoda. // Vopr Onkol. 2005;51(2):230-1.[Sherbakov AM. Endoscopic argon-plasma coagulation application in palliative treatment of recurrent stomach cancer at the esophageal anastomosis. // Vopr Onkol. 2005;51(2):230-1. (In Russ).]. https://doi.org/10.1272/jnms.74.163 10. Harada S, Sakakibara Y, Ishida H, Mori K, Mita E. Early Gastric Cancer Arising From Hyperplastic Polyps After Argon Plasma Coagulation for Gastric Vascular Ectasia. // ACG Case Rep J. 2023 Jan 13;10(1):e00953. https://doi.org/10.14309/crj.0000000000000953 11. Grynd K.E., Cindel K., Farin G. Prakticheskie ykazaniya po primeneniu metoda argonoplazmennoi koagylyacii (ARS) v «gibkoi» endoskopii // Endoskopiya segodnya. - 1996. - № 4. - S. 338-343 [Grund K.E., Tsindel K., Farin G. Practical guidelines for the use of the argon plasma coagulation (APC) method in flexible endoscopy. // Endoscopy today. - 1996. - No. 4. - S. 338-343. (In Russ).]. 12. Reijm AN, Zellenrath PA, van der Bogt RD, van Driel LMJW, Siersema PD, Bruno MJ, Spaander MCW. Self-expandable duodenal metal stent placement for the palliation of gastric outlet obstruction over the past 20 years. // Endoscopy. 2022 Dec;54(12):1139-1146. https://doi.org/10.1055/a-1838-5642 13. Kopecky K, Monton O, Rosman L, Johnston F. Palliative interventions for patients with advanced gastric cancer: a systematic review. // Chin Clin Oncol. 2022 Dec;11(6):47. https://doi.org/10.21037/cco-22-102 14. Terashita D, Gakuhara A, Fukuda S, Tomihara H, Ota K, Kitani K, Hashimoto K, Ishikawa H, Hida J, Kimura Y. Fracture of a Gastrointestinal Stent during Chemotherapy for Unresectable Advanced Gastric Cancer-A Case Report. Gan To Kagaku Ryoho. 2022 Dec;49(13):1841-1843. Japanese. PMID: 36733017. 15. Ko SW, So H, Bang SJ. Gastric Perforation Encountered during Duodenal Stent Insertion. // Korean J Gastroenterol. 2022 Nov 25;80(5):221-224. https://doi.org/10.4166/kjg.2022.060 16. Kanno Y, Ito K, Fujita N, Noda Y, Kobayashi G, Horaguchi J, Koshita S, Ogawa T, Masu K, Hirasawa D, Sugawara T, Koike Y, Hashimoto S, Ishii S. Efficacy and safety of a WallFlex enteral stent for malignant gastric obstruction. // Dig Endosc. 2013 Jul;25(4):386-91. https://doi.org/10.1111/j.1443-1661.2012.01396.x. 17. Abdelhakeem, A.A.; Wang, X.; Waters, R.E.; Patnana, M.; Estrella, J.S.; Blum Murphy, M.; Trail, A.M.; Lu, Y.; Devine, C.E.; Ikoma, N.; et al. Preoperatively Treated Diffuse-Type Gastric Adenocarcinoma: Glucose vs. Other Energy Sources Substantially Influence Prognosis and Therapy Response. // Cancers 2021, 13, 420. https://doi.org/10.3390/cancers13030420 18. Ali M, Wang Y, Ding J, Wang D. Postoperative outcomes in robotic gastric resection compared with laparoscopic gastric resection in gastric cancer: A meta-analysis and systemic review. // Health Sci Rep. 2022 Aug 16;5(5):e746. https://doi.org/10.1002/hsr2.746 19. Zaicev D.A., Natha A.S., Belyaev M.A., Hamid A.H., Vovin K.N., Kypenskaya T.V., Vervekin I.V., Svechkova A.A., Zaharenko A.A. Vnytribrushinnaya himioterapiya pri rake jelydka (OBZOR LITERATYRI). // Medline.ru. 2023 |
|||||||||
Articles
| Размещение рекламы | |
| |
 |