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Vol. 23, Art. 48 (pp. 792-800)    |    2022       

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Anti-yo encephalitis: case report and literature review

Sokhatskaya Yu.M.1, Vaskova N.L.1, Subbotina D.R.2,3, Chistova I.V.3, Sulin K.A.1, Krasnoshlyk P.V.1, Gulyaev D.A.1

1 Almazov National Medical Research Centre, 2, Akkuratova st., Saint-Petersburg, 197341, Russia
2 North-Western State Medical University named after I.I. Mechnikov, Piskarevsky pr., Saint-Petersburg, 195067, Russia
3 NMRC of Oncology named after N.N.Petrov of MoH of Russia, Leningradskaya st., 68, Saint-Petersburg, 197758, Russia

Brief summary

Anti-Yo encephalitis is considered in the structure of paraneoplastic autoimmune neurological syndrome in the form of subacute cerebellar degeneration with the development of corresponding cerebellar symptoms. This disease is characterized by the development of an autoimmune lesion of the cerebellum with the production of cytoplasmic antibodies to type 1 Purkinje cells due to the presence of an oncological process in the patient's body. The aim of this work is to describe a clinical example of anti-Yo encephalitis with damage to the cerebellar vermis before the diagnosis of an oncological process in the mammary gland, which directly provoked the development of a paraneoplastic autoimmune neurological syndrome. Careful differential diagnosis in such cases helps to avoid unnecessary traumatic surgical intervention and contribute to a more extensive oncology search with subsequent identification of clinically significant foci of malignant neoplasms.


Key words

mammary cancer; paraneoplastic autoimmune neurological syndrome

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