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Vol. 23, Art. 47 (pp. 780-791)    |    2022       

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Comparative evaluation of pharmacokinetic parameters of ca-dtpa and zn-dtpa in blood plasma and lung tissues of rats after intravenous and intratracheal administration

Sventitskaya A.M., Ivanov I.M., Tsoy D.V., Nikiforov A.S., Raguzin E.V., Alhutova I.M., Neeshpapa A.D.

Federal State Budgetary Institution «State Scientific Research Test Institute of military medicine», Ministry of Defense of the Russian Federation

Brief summary

The incorporation of radionuclides during their inhalation into the human body remains an urgent problem in emergency situations at nuclear industry facilities. Complexones based on diethylenetriaminepentaacetic acid Ca-DTPA and Zn-DTPA have proven efficacy when administered intravenously. The development of a promising direction for the inhalation administration of complexones requires a comparative pharmacokinetic study of these drugs. The established pharmacokinetic parameters of Ca-DTPA after intratracheal administration to rats indicated a rapid and complete intake of the drug from the lungs into systemic circulation, preferential distribution in blood plasma and low penetration into tissues, as well as rapid excretion from the body. These features may determine the preference for inhaled use of Ca-DTPA for the decorporation of radionuclides from the lungs in comparison with Zn-DTPA.


Key words

diethylenetriaminepentaacetic acid; complexones; Ca-DTPA; Zn-DTPA; pharmacokinetic parameters; intratracheal administration; blood plasma; lung tissues

Reference list

1. Kovtyn V.U., Gladkih V.D., Davidovich U.A. [i dr.] K voprosy ob ispolzovanii lekarstvennih form pentacina i cinkacina. Medicinskaya radiologiya i radiacionnaya bezopasnost. 2015; 60 (1): 45-53.


2. Radionyklidi i proizvodstvennaya deyatelnost cheloveka: Spravochnik / pod red. L.A. Byldakova, V.S. Kalistratovoi. M.: FYMBiEP; 1997.


3. Peron N., Le Guen P., Andrieu V. [et al.] Inhalation therapy: inhaled generics, inhaled antidotes, the future of anti-infectives and the indications of inhaled pentamidine. Rev Mal Respir. 2013; 30 (10): 832-842.


4. Koizumi A., Fukuda S., Yamada Y. [et al.] Dosage of DTPA Administration by Inhalation // International Congress of the International Radiation Protection Association, Hiroshima, Japan. [Elektronnii resyrs]. 2000. Rejim dostypa: http://www.irpa.net/irpa10/cdrom/00302.pdf