Опубликовать статью

Информационное партнерство

Инфоресурсы

Контакты

«

Vol. 22, Art. 29 (pp. 426-436)    |    2021       

»

New derivatives of 8-aminoalloxazine - flavin analogues with promising pharmacological properties

Dobrenko M.A., Sukhova A.S., Krasnov K.A.

St. Petersburg State Institute of Technology (Technical University)
The Federal State-Financed Institution Golikov Research Clinical Center of Toxicology under the Federal Medical Biological Agency

Brief summary

New derivatives of 8-aminoalloxazine were obtained and studied by physico-chemical methods. The virtual assessment of the biological properties of the synthesized compounds carried out using the PASS Online program allows us to expect with a high probability the effects associated with selective exposure to riboflavin-dependent enzyme systems, enzymes of xenobiotic metabolism, as well as the presence of respiratory-analeptic activity in substances.


Key words

8-aminoalloxazines, synthesis, Piloty?s reaction, flavins, analogues.

Reference list

1.Korotchenkova, N.V. Himicheskaya tehnologiya vitaminov: ychebnoe posobie/ N.V. Korotchenkova, A.A. Iozep. - SPb.: Prospekt Nayki, 2012. - 224 s.


2. Soldatenkov, A.T. Osnovi organicheskoi himii lekarstvennih veshestv/ A.T. Soldatenkov, N.M. Kolyadina, I.V. Shendrik. - M.: Himiya, 2001. - 192 s.


3. Lee E.R., Roseoflavin is a natural antibacterial compound that binds to FMN riboswitches and regulates gene expression/ E.R. Lee, K.F. Blount, R.R. Breaker// RNA Biol. - 2009 - Vol. 6, 2. - P. 187-194.


4. Müller, F. Ed. Chemistry and Biochemistry of Flavoenzymes: Volume II// F. Ed. Müller. CRC Press, 1991 - P. 516.


5. Kubota, A. Alkoxyresorufin (methoxy-, ethoxy-, pentoxy- and benzyloxyresorufin) O-dealkylase activities by in vitro-expressed cytochrome P450 1A4 and 1A5 from common cormorant (Phalacrocorax carbo)/ A. Kubota, E.-Y. Kim, H. Iwata// Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology. - 2009 - Vol. 149, 4. - P. 544-551.


6. Lubet, R.A. The induction of alkoxyresorufin metabolism: A potential indicator of environmental contamination/ R.A. Lubet, F.P. Guengerich, R.W. Nims// Archives of Environmental Contamination and Toxicology. - 1990 - Vol. 19, ? 2. - P. 157-163.


7. Berezovskii, V.M. Himiya allo- i izoalloksazinov / V.M. Berezovskii, T.V. Eremenko// Yspehi himii. - 1963. - T. 32, 6. - S. 671-706.


8. Halladay, P. K. An Investigation of Benzo[g]pteridine-2,4(3H,10H)-diones (Flavins) as Antimalarials: A Thesis submitted for the Degree of Doctor of Philosophy of The Australian National University, 1990. 146 p.


9. EP 1471940 (A2) MPK A61K 35/14 Inactivation of west nile virus and plasmodium falciparum using alloxazine-derivating photosensitisers /Reddy H., Goodrich R.P. Published 03.11.2004.


10. Piloty, O. Ueber die Harnsäuregruppe / O. Piloty, K. Finckh // Leib. Ann. - 1904. - Bd. 333, 1. - S. 22-71.


11. Biltz, H. 5-Nitrobarbitursäuren / H. Biltz, K. Sedlatscheck// Chem. Ber. - 1924. - Bd. 57, 2. - S. 339-349.