Опубликовать статью

Информационное партнерство

Инфоресурсы

Контакты

«

Vol. 18, Art. 22 (pp. 313-321)    |    2017       

»

Genetic markers and biochemical characteristics of the comorbidity in patients with severe hemophilia, associated with oxidative stress

Kargin V.D., Soldatenkov V.E., Kapustin S.I., Chechetkin A.V., Bessmeltsev S.S., Burakov V.V., Rybakova L.P., Aleksanyan L.R., Shmeleva V.M., Smirnova O.A., Papayan L.P., Titov A.G., Komissarov K.A.

Russian Research Institute of Hematology and Transfusiology, St-Petersburg, Russia

Brief summary

The results of the study of comorbidity in patients with severe hemophilia, associated with metabolic disorders of homocysteine and expression of oxidative aggression, are presented. The frequency of hyperhomocysteinemia as an inducer of oxidative stress, as well as condition of lipid peroxidation and antioxidative protection, involved in the progression of joint disease in patients with hemophilia, have been studied. Based on genetic and biochemical data, the origin of hyperhomocysteintmia and oxidative disorders and their role in comorbidity in patients with severe hemophilia has been established, as well as the predictors of those disorders were identified.


Key words

hemophilia, genetic, prognostic factor, hyperhomocysteintmia, comorbidity

Reference list

1. Starfield B., Lemke K.W., Bernhardt T. Comorbidity: Implications for the Importance of Primary Care in Case Management //?Ann Fam Med, 2003; 1(1):8-14.? Ann?Fam?Med,?2003;?1(1):8-14.


2. Van?Weel?C.,?Schellevis?F.G.?Comorbidity?and?guidelines:?conflicting?interests?//?Lancet,?2006;?367:550-551.


3. Gill?T.,?Feinstein?A.R.?A?critical?appraisal?of?the?qualitylife?measurements?//?JAMA,?1994;?272:619-626.


4. Van?den?Akker?M.,?Buntinx?F.,?Roos?S.,?Knottnerus?J.A.?Comorbidity?or?multimorbidity:?what?s?in?a?name??Areview?of?the?literature?//?Eur?J?Gen?Pract,?1996;?2(2):65-70.


5. Belyalov?F.?I.?Lechenie?vnytrennih?boleznei?v?ysloviyah?komorbidnosti?//?Monografiya;?


2-e?izd.,?Irkytsk, 2010.


6. I.A. Blajievich Klinicheskie osobennosti, komorbidnost i effektivnost terapii gemofilii// Avtoref. diss.... kand. med. nayk ? Novosibirsk. 2009. S.25.


7. Bessmelcev S.S., Abdylkadirov K.M. Yltrazvykovaya diagnostika. Sankt-Peterbyrg, Izdatelstvo KN. ?1997. ? S.114-119.


8. G. Roosendaal, M.E. Vianen, M.J.G. Wenting et al. Iron deposits and catabolic properties of synovial tissue from patients with hemophilia // J Bone Joint Surg. Br. ?1998. ? Vol. 80. ? P. 540-545.


9. Arytunyan A.V., Dybinina E.E., Zibina N.N. Metodi ocenki svobodnoradikalnogo okisleniya i antioksidantnoi sistemi organizma // Metodicheskie rekomendacii. ? SPb: IKF ?Foliant?, 2000. ? 104 S.