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Vol. 13, Art. 57 (pp. 682-700)    |    2012       

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Radioprotective properties of modern antioxidants

Tarumov R.A., Basharin V.A., Grebenyuk A.N.

Medical Military Academy named after S.M. Kirov

Brief summary

Every year the problem of chemical defense against exposure to ionizing radiation becomes more and more important. The attempts are being made to find new pharmacological agents that a high radioprotective efficacy and low toxicity. They have to be equally effective, safe and convenient to use. In present time antioxidants are being considered as a promising radioprotective drugs.


Key words

radiation, radiation injuries, radioprotector, treatment, antioxidant.

Reference list

1. Asadyllina N.R. Antioksidantnie svoistva ksantozina pri vozdeistvii rentgenovskogo izlycheniya / N.R. Asadyllina, S.V. Gydkov, V.I. Bryskov // Fyndamentalnie issledovaniya. – 2011. – № 10. – S. 22-25.


2. Asadyllina N.R. Radiozashitnie svoistva ryada pyrinovih soedinenii: Avtoref. diss. … kand. biol. nayk / N.R. Asadyllina. – M., 2012. – 26 s.


3. Byrlakova E.B. Antioksidanti. Termini i opredeleniya / E.B. Byrlakova, V.M. Misin, N.G. Hrapova, A.U. Zavyalov. – M.: Izd-vo RYDN, 2010. – 63 s.


4. Vereshako G.G. Protivolychevie svoistva selenometionina s metioninom / G.G. Vereshako, A.M. Hodosovskaya // Aktyalnie problemi toksikologii i radiobiologii: Tez. dokl. Ros. naych. konf. s mejdynar. ychastiem. – SPb: Foliant, 2011. – S. 219


5. Golichenkov V.A. Melatonin kak antioksidant: osnovnie fynkcii i svoistva / V.A. Golichenkov, A.U. Bespyatih, O.V. Byrlakova // Ysp. sovrem. biol. – 2010. – № 5. – S. 487-496.


6. Ivanov A.A. Protivolychevaya effektivnost laktoferrina / A.A. Ivanov, A.M. Ylanova, N.M. Stavrakova i dr. // Radiac. biologiya. Radioekologiya. – 2009. – T. 49, № 4. – S. 456-461.


7. Magira V.F. Kliniko-eksperimentalnoe obosnovanie rannego kompleksnogo primeneniya antioksidantov pri radiacionnih vozdeistviyah na organizm: Avtoref. diss… kand. med. nayk / V.F. Magira. – SPb, 2002. – 26 s.


8. Menshikova E.B. Okislitelnii stress. Prooksidanti i antioksidanti / E.B. Menshikova, V.Z. Lankin, N.K. Zenkov i dr. – M.: Firma «Slovo», 2006. – 556 s.


9. Mikylyak N.I. Eksperimentalnoe issledovanie effektivnosti preparata s antioksidantnim tipom deistviya – meksidola na gemostaz pri lychevoi terapii / N.I. Mikylyak, P.V. Ivanov, A.G. Zaharkin // Kybanskii naych. med. vestn. – 2009. – № 1. – R. 72- 76.


10. Mil E.M. Vliyanie antioksidanta fenozana i oblycheniya v maloi doze na soderjanie belkov r53 i bcl-2 y mishei raznih linii / E.M. Mil, A.A. Albantova, E.B. Byrlakova // Radiac. biologiya. Radioekologiya. – 2010. – T. 50, № 1. – S. 58-64.


11. Moroz B.B. Vliyanie meksidola na postradiacionnoe vosstanovlenie krovetvornoi sistemi / B.B. Moroz, U.B. Deshevoi, G.V. Sykoyan i dr. // Radiac. biologiya. Radioekologiya. – 2009. – T. 49, № 1. – S. 90-96.


12. Pikalova L.V. Genoprotektivnie effekti melatonina pri himicheskih i radiacionnih vozdeistviyah: Avtoref. diss. … kand. med. nayk / L.V. Pikalova. – SPb, 2012. – 23 s.


13. Bakir M.A. Radioprotective effects of selenium in rats / M.A. Bakir, G. Alya, A. Mohammad et al. // J. Radioanal. Nucl. Chem. – 2005. – Vol. 266, № 2. – P. 165-170


14. Bhatia A.L. Radiation protection by an isoflavone, genistein: a study on the survivability of mice / A.L. Bhatia, A. Gaur, A. Sharma // Nucl. Techn. Rad. Protect. − 2007. − Vol. 22, № 1.− P. 34-39.


15. Calveley V.L. Genistein can mitigate the effect of radiation on rat lung tissue / V.L. Calveley, S. Jelveh, A. Langan et al. // Radiat. Res. – 2010. – Vol. 173, № 5. – R. 602-611.


16. Davis T.A. Genistein induces radioprotection by hematopoietic stem cell quiescence / T.A. Davis, O. Mungunsukh, S. Zins et al. // Int. J. Radiat. Biol. – 2008. – Vol. 84, № 9. – R. 713-726.


17. Davis T.A. Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival / T.A. Davis, T.K. Clarke, S.R. Mog, M.R. Landauer // Int. J. Radiat. Biol. – 2007. – Vol. 83, № 3. – P. 141-151.


18. Day R.M. Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation / R.M. Day, M. Barshishat-Kupper, S.R. Mog et al. // J. Radiat. Res. – 2008. – Vol. 49, № 4. – R. 361-372.


19. Epperly M.W. Mitochondrial targeting of a catalase transgene product by plasmid liposomes increases radioresistance in vitro and in vivo / M.W. Epperly, J.A. Melendezc, X. Zhanga et al. // Radiat. Res. – 2009. – Vol. 171, № 5. – R. 588-595.


20. Jagetia G.C. Radioprotective potential of plants and herbs against the effects of ionizing radiation / G.C. Jagetia // J. Clin. Biochem. Nutr. – 2007. – Vol. 40, № 1. – P. 74-81.


21. Kilsiksiz S. The effect of N-acetylcysteine on biomarkers for radiation-induced oxidative damage in a rat model / S. Kilsiksiz, C. Demirel, N. Fridal et al. // Acta Med. Ocayama. – 2008. – Vol. 62, № 6. – R. 403-409.


22. Koc M. The effect of melatonin on peripheral blood cells during total body irradiation in rats / M. Koc, M.E. Buyukokuroglu, S. Taysi et al. // Biol. Pharm. Bull. – 2002. – Vol. 25, № 5. – P. 656-657.


23. Kumar K.S. Nutritional approaches to radioprotection: vitamin E / K.S. Kumar, V. Srinivasan, R. Toles et al. // Military Med. – 2002. – Vol. 167, № 1. – R. 57-59.


24. Kruk I. Scavenging of reactive oxygen species by the plant phenols genistein and oleuropein / I. Kruk, H.Y. Aboul-Enein, T. Michalska et al. // Luminescence. – 2005. – Vol. 20, № 2. – R. 81-89.


25. Manda K. α-Lipoic acid attenuates X-irradiation-induced oxidative stress in mice / K. Manda, M. Ueno, T. Moritake et al. // Cell Biol. Toxicol. – 2007. – Vol. 23, № 2. – R. 129- 137.


26. Mortensen A. Analytical and compositional aspects of isoflavones in food and their biological effects / A. Mortensen, S.E. Kulling, H. Schwartz et al. // Mol. Nutr. & Food Res. – 2009. – Vol. 53, Is. S2. – P. S266-S309.


27. Landauer M.R. Genistein treatment protects mice from ionizing radiation injury / M.R. Landauer, V. Srinivasan, T.M. Seed et al. // J. Appl. Toxicol. – 2003. – Vol. 23. – R. 379- 385.


28. Landauer M.R. Phytoestrogenic isoflavone compositions, their preparation and use thereof for protection against and treatment of radiation injury / M.R. Landauer, T.M. Seed, V. Srinivasan et al. // Patent application publication N US 2010/0197779 A1. − 2010.


29. Landauer M.R. Protection against lethal irradiation by genistein / M.R. Landauer, S.V. Srinivasan, A. Shapiro et al. // Int. J. Toxicol. − 2000. − № 19. − P. 37-43.


30. Okunieff P. Antioxidants reduce consequences of radiation exposure / P. Okunieff, S. Swarts, P. Keng et al. // Adv. Exp. Med. Biol. – 2008. – Vol. 614. – R. 165-178.


31. Reiter R. Melatonin as a radioprotective agent / R. Reiter, D. Tan, T. Herman et al. // Int. J. Radiat. Oncol. Biol. Phys. – 2004. – Vol. 59, № 3. – P. 639-653.


32. Satyamitra M. In vivo postirradiation protection by a vitamin E analog, alpha- TMG / M. Satyamitra, D.P. Uma, H. Murase et al. // Radiat. Res. – 2003. – Vol. 160, № 6. – R. 655-661.


33. Seed T.M. Radiation protectants: current status and future prospects / T.M. Seed // Health Phys. – 2005. – Vol. 89, № 5. – R. 531-545.


34. Singh V.K. Effects of genistein administration on cytokine induction in wholebody gamma irradiated mice / V.K. Singh, M.B. Grace, V.I. Parekh et al. // Int. Immunopharmacol. – 2009. – Vol. 9, № 12. – R. 1401-1410.


35. Song L-H. Protective effects of soybean isoflavone gamma-irradiation induced damages in mice / L.-H. Song, H.-L. Yan, D.-L. Cai // J. Radiat. Res. − 2006. – Vol. 47. − P. 157-165.


36. Sorenson J.R. Essential metalloelement chelates facilitate repair of radiation injury / J.R. Sorenson, S.F. Soderberg, L.W. Chang at al. // Met. Based Drugs. – 2001. – Vol. 8, № 4. – R. 215-284.


37. Tabaczar S. Nitroxides as antioxidants – possibilities of their application in chemoprevention and radioprotection / S. Tabaczar, M. Talar, K. Gwozdzinski et al. // Postepy Hig. Med. Dosw. – 2011. – Vol. 65. – P. 46-54.


38. Traganos F. Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells / F. Traganos, V. Ardelt, N. Halko et al. // Cancer Res. − 1992. − Vol. 52, № 22. − P. 6200-6208.


39. Verdrengh M. Genistein as an anti-inflammatory agent / M. Verdrengh, I.M. Jonsson, R. Holmdahl et al. // Inflam. Res. – 2003. – Vol. 52, № 8. – R. 341-346.


40. Wei H. Antioxidant and antipromotional effects of the soyabean isoflavone genistein / H. Wei, R. Bowen, Q. Cai et al. // Proc. Soc. Exp. Biol. Med. − 1998. − Vol. 208. − P. 124-130.


41. Weiss J.F. Radioprotection by antioxidants / J.F. Weiss, M.R. Landauer // Ann. N. Y. Acad. Sci. – 2000. – Vol. 899. – R. 44-60.


42. Whanger P.D. Selenocompounds in plants and animals and their biological significance / P.D. Whanger // J. Am. Coll. Nutr. – 2002. – Vol. 21, № 3. – R. 223-232.


43. Zhang Y.C. Isoflavone profile and biological activity of soya bread // Y.C. Zhang, D. Albrecht, J. Bomer et al. // J. Agric. Food Chem. − 2003. − Vol. 51. − P. 7611-7616.


44. Zhao W. Oxidative damage pathways in relation to normal tissue injury / W. Zhao, D.I. Diz, M.E. Robbins // Br. J. Radiol. – 2007. – Vol. 80. – P. 23-31.


45. Zhou Y. Genistein stimulates hematopoiesis and increases survival in irradiated mice / Y. Zhou, M. Mi // J. Radiat. Res. – 2005. – Vol. 46. – R. 425-433.