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Vol. 12, Art. 39 (pp. 464-473)    |    2011       

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Assess the level of endogenous intoxication in tumor intestinal obstruction

Belayev A.M., Luft, V.M., Babkov O.V., Zacharenko A.A., Surov D.A., Alekseev V.V., Kondratsov S.A., Rudakov D.A., Ivanitskii S.A., Lapitskii A.V.

Djanelidze Research Institute of Emergency Medicine, Saint Petersburg, Russia

Brief summary

In modern colorectal cancer surgery a large number of inflammatory complications and high mortality in the postoperative period are observed. This situation is explained by the development and later progression of endogenous intoxication in this group of patients during the postoperative period. This is a polyetiological and polypathogenetic syndrome characterized by the accumulation of endogenous toxic substances - an excess of products of normal or perverted metabolism or cellular response - in body fluids. The presence of endogenous intoxication in these patients provides the prerequisites for the application of complementary therapies in the postoperative period, using which we will observe reduction of the syndrome. In this case, the method of early enteral therapy and nutritional support was used. The study empirically proved that the use of this technique for the malignant intestinal obstruction managing promotes a faster reduction of the endotoxemia effects.


Key words

endogenous intoxication, molecules of average weight, WBC intoxication index, enteric therapy, nutritional support, colorectal cancer, inflammatory complications, intestinal obstruction.

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