Оncomarkers expression in foci of adenomyosis: clinicomorphological and immunohistochemical characteristic (analysis)
E.Kogan1, Т.Demura1, N.Nizyaeva1, L.Еzova3, А. Unanyan2, I.Sidorova2
1 - Anatomic pathology department (chief department, RAS and RAMS acad., prof. М.Paltchev), Sechenov Moscow Medical Academy, 119991, Moscow ,
2 - Obstetric and gynecological department (chief department, RAMS acad, prof. I.Sidorova), Sechenov Moscow Medical Academy, 119991, Моscow
3 - Research center for obstetric, gynecology and perinatology (director, RАМS acad. prof. H.Sukchikch), 117997, Моscow
The aim of our study was to investigate morphological variants and molecular changes in epithelium of adenomyotic foci in combination with endometrial adenocarcinoma (EAC). The study was performed on surgical material of excised uteri from patients with adenomyosis (33 patients) and with combination of adenomyosis and EAC (37). ApoCas, Claudin 2, 3, 5, Ki-67, ММР-2, 9, TIMP-1, E-cadherin, COX-2, EGFR, VEGF. We found the following changes in epithelium in AM foci: proliferation stage endometrium, hyperplasia with and without athypia and atrophy. ApoCas, Ki-67, MMP-2,9, COX-2, VEGF, EGFR expression increased from epithelium of proliferation stage, to hyperplasia without and with athypia, and it was the highest in EAC. Epithelial foci with athypical endometrial hyperplasia had increased expression of Ki-67 and EGFR, decreased - ApoCas and E-cadherine, and changes in MMPs, TIMPs and claudins expression patterns. Obtained results suggest that adenomyotic foci adjacent to EAC may undergo malignant transformation as a result of influence from cytokins of cancer origin.