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 УЧРЕДИТЕЛИ:
Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН"

ФГБУН "Институт токсикологии" ФМБА России




Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

Свидетельство о регистрации электронного периодического издания ЭЛ № ФС 77-37726 от 13.10.2009
Выдано - Роскомнадзор

ISSN 1999-6314

Российская поисковая система
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«
Vol. 24, Art. 81 (pp. 1172-1179)    |    2023       
»

Pathophysiological aspects of scar tissue formation in combat trauma
Sobolev D.V., Kishenya M.S., Visyagin A.V., Anchikova E.V.

1State educational organization of Higher professional education "Donetsk National Medical University named after M.Gorky"
2MedVitro Limited Liability Company



Brief summary

Wound healing involving the processes of inflammation, proliferation and remodeling requires a dynamic study of the clinical and pathogenetic mechanisms and risk factors involved in the formation of scars that cause structural, functional and cosmetic negative consequences. The aim of the work was a dynamic study of the formation of scar tissue in patients with surgical interventions for wounds and traumatic injuries. Out of 196 people (148 men and 48 women) aged 18 to 56 years, 2 groups of patients were formed after surgery: with a healing period of less than 14 days (group I - 97 people) and more than 14 days (group II - 99 people). The process of formation of postoperative scars was evaluated 3, 6, 9 and 12 months after wound healing using the VSS scale. After 12 months, pathological scars were detected in 72 people (42%), normotrophic - in 100 people (58%): in group I, pathological scars were detected in 8 people (9.76%), normotrophic - in 89 people (90.24%); in group II, pathological scars were detected in 64 patients (72.73%), normotrophic - in 24 patients (27.27%), which characterized the development of hyperfibrosis with prolonged inflammation for more than 14 days during wound healing. In patients with follow-up periods of 9 and 12 months, there were no differences in VSS in group I (p=0.088) II (p=0.067), which indicated similar signs of the structure of scar tissue and its formation during 9 months of follow-up. The intensity of scar tissue formation was more pronounced during the long course of the wound process, which has signs of chronic inflammation.


Key words

pathological scars; combat injury; wound process; Vancouver scar scale





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