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 УЧРЕДИТЕЛИ:
Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН"

ФГБУН "Институт токсикологии" ФМБА России




Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

Свидетельство о регистрации электронного периодического издания ЭЛ № ФС 77-37726 от 13.10.2009
Выдано - Роскомнадзор

ISSN 1999-6314

Российская поисковая система
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«
Vol. 24, Art. 54 (pp. 729-738)    |    2023       
»

Acute kidney injury in toxicology clinic: the main causes of development in everyday practice
Kuznetsov O.A.1,2, Shilov V.V.1,2, Fedorov A.V.1

1Saint-Petersburg I.I. Dzanelidze research institute of emergency medicine,
2North-Western State Medical University named after I.I. Mechnikov



Brief summary

Acute kidney injury (AKI) is one of the complications in patients with acute poisoning, which aggravates the condition and affects the outcome of acute chemical trauma. Materials and methods. The analysis of 203 cases of AKI development in patients with acute poisoning was carried out. The data on the causes of AKI development in the toxicology clinic are summarized. Results. It was revealed that for the period 2018-2020. the course of poisoning was complicated by the development of AKI in 4.57% of cases (203 patients). The most common cause was poisoning with synthetic drugs, such as methadone, amphetamine, alpha-PVP. The genesis of AKI development was primarily associated with the development of rhabdomyolysis: local (positional compression syndrome), systemic, which developed as a result of the action of these drugs. Also, the development of AKI was noted in poisoning with various psychopharmacological drugs, preparations affecting mainly the cardiovascular system, toxic alcohols and poisons of cauterizing action. In isolated cases, the development of AKI has been reported in cases of poisoning with paracetamol and amanitines. The cause of AKI was a combination of both renal factors (direct nephrotoxicity) and prerenal factors, such as hypovolenemia and long-lasting hypotension. Conclusion. Most often, AKI develops with poisoning with synthetic drugs, psychopharmacological drugs and toxic alcohols. The development of AKI is one of the severe complications of the disease, which leads to an increase in mortality and the need for replacement therapy.


Key words

poisoning; acute kidney injury; pathogenesis





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