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 УЧРЕДИТЕЛИ:
Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН"

ФГБУН "Институт токсикологии" ФМБА России




Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

Свидетельство о регистрации электронного периодического издания ЭЛ № ФС 77-37726 от 13.10.2009
Выдано - Роскомнадзор

ISSN 1999-6314

Российская поисковая система
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«
Vol. 23, Art. 31 (pp. 556-572)    |    2022       
»

Historical aspects of the study and practical application of plant toxins ricin and abrin
Nikishin A.S., Myasnikov V.A., Ilinskiy N.S., Pugach V.A.

State Scientific Research Testing Institute of Military Medicine of the Ministry of Defense of Russia



Brief summary

The paper presents the historical aspects of the study and practical application of lectins of plant origin, ricin and abrin. The two most actual vectors of their consideration today are reflected. One of them concerns the issues of development of effective antitumor agents based on toxins and the other one is about potential threat of use the toxins as biological damaging agents. The discussion of the first direction includes a demonstration of the main achievements and existing problems that limit the introduction of the drugs into clinical practice. The second one involves generalization of facts that arguing the preservation of a high probability of using ricin and/or abrin as a means of bioterrorism and the need to improve countermeasures in this regard


Key words

ricin, abrin, study history, biological damaging agents, antitumor agents.





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