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Vol. 19, Art. 52 (pp. 705-720)    |    2018       

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Constitutional and neurohumoral features in the premature cardiac contractions diagnostics in healthy individuals of later adolescence

Stepanenko I.A., Salukhov V.V., Kitsyshin V.P., Arsentiev V.G.,
Izilyaeva E.A., Novikov I.I., Shalnev M.P., Surzhikov P.V., Meshkova M.E.
S.M. Kirov Military Medical Academy, Saint Petersburg, Russia

Brief summary

To assess the diagnostic significance of some data of physical, laboratory and instrumental examinations for the detection of rhythm disturbances. Methods: Forty-four adolescents aged 15-19 years old (mean age 17.2 years) were examined. Using screening diagnostics, signs of connective tissue dysplasia were assessed. Performed ambulatory ECG monitoring and biochemical blood test. Results: In the examined patients, premature atrial contractions (PAC) and premature ventricular contractions (PVC) were detected in 98% and 43% of cases respectively. In 7.7% of cases, transient second-degree atrioventricular block type I was observed. In 73.1% of cases, sinus pauses with a duration of more than 1500 ms were detected. A weak negative correlation of the number of points from the screening diagnostics of connective tissue dysplasia (CTD) with the number of PACs (rs = -0.351, p = 0.011) and a weak direct relationship between PACs and PVCs (rs = 0.305, p = 0.028) was demonstrated. In the group with a larger number of dysplastic signs, the waist to hip ratio (WHR) and the level of total bilirubin were statistically significant lesser with respect to the group with a fewer CTD diagnostics points (p <0.05). In the group with a larger number of PACs (≥7 PACs per 24 hours) levels of urea (p=0.006), creatinine (p=0.04), total bilirubin (p=0.04), iron were lower (p = 0.0004). In persons who did not have a PVC during the 24h ECG monitoring, WHR was higher than in the group where at least one premature ventricular beat was registered (p = 0.003). Conclusion: Higher levels of serum iron and total bilirubin correspond to a lower frequency of premature atrial contractions. WHR take on larger values in individuals without ventricular ectopic beats.


Key words

premature atrial contractions, premature ventricular contractions, adolescence, constitution, connective tissue dysplasia, heart rate variability, Ambulatory ECG monitoring.

Reference list

1. Andreeva, A.U. Konstitycionalno-morfologicheskie osobennosti formirovaniya i klinicheskogo techeniya naryshenii ritma serdca i provodimosti y detei : dissertaciya ... kandidata medicinskih nayk : 14.00.09 / A.U. Andreeva. - Krasnoyarsk : [Mesto zashiti: GOYVPO «Krasnoyarskaya gosydarstvennaya medicinskaya akademiya»], 2004. - 127 s.


2. Distribution and categorization of echocardiographic measurements in relation to reference limits: the Framingham Heart Study: formulation of a height- and sex-specific classification and its prospective validation / R.S. Vasan [et al.] // Circulation. - 1997. - Vol. 96, N 6. - P. 1863-1873.


3. Premature atrial contractions in the general population: frequency and risk factors / D. Conen [et al.] // Circulation. - 2012. - Vol. 126, N 19. - P. 2302-2308.


4. The impact of height on the risk of atrial fibrillation: the Cardiovascular Health Study / M.A. Rosenberg [i dr.] // Eur. Heart J. - 2012. - T. 33, ? 21. - S. 2709-2717.


5. Risk factors for premature ventricular contractions in young and healthy adults / M. von Rotz [et al.] // Heart Br. Card. Soc. - 2017. - Vol. 103, N 9. - P. 702-707.


6. Galaktionova, M.U. Morfofynkcionalnie kriterii displazii soedinitelnoi tkani y detei s narysheniyami ritmicheskoi deyatelnosti serdca / M.U. Galaktionova // Pediatricheskie aspekti displazii soedinitelnoi tkani. Dostijeniya i perspektivi: Ros. sb. naychn. tr. / red. S.F. Gnysaev, T.I. Kadyrina, A.N. Semyachnika. - M. [i dr.] : OOO RG «PRE100», 2011. - T. 2. - S. 236-243.


7. Gnysaev, S.F. Sindrom soedinitelno-tkannoi displazii serdca y detei / S.F. Gnysaev // Lechashii vrach. - 2010. - ? 8. - S. 40-44.


8. Zemcovskii, E.V. Displasticheskie fenotipi. Displasticheskoe serdce: analiticheskii obzor / E.V. Zemcovskii. - SPb. : Izd-vo Olga, 2007. - 80 s.


9. The relationship between serum sex steroid levels and heart rate variability parameters in males and the effect of age / M.T. Doğru [et al.] // Turk Kardiyol. Dernegi Arsivi Turk Kardiyol. Derneginin Yayin Organidir. - 2010. - Vol. 38, N 7. - P. 459-465.


10. Heart rate variability and electrical stability / T. Fetsch [et al.] // Basic Res. Cardiol. - 1998. - Vol. 93 Suppl 1. - P. 117-124.


11. Assessment of the effects of frequent ventricular extrasystoles on the left ventricle using speckle tracking echocardiography in apparently normal hearts / A. Barutçu [et al.] // Anatol. J. Cardiol. - 2016. - Vol. 16, N 1. - P. 48-54.


12. Bazett, H.C. The time relations of the blood-pressure changes after excision of the adrenal glands, with some observations on blood volume changes / H.C. Bazett // J. Physiol. - 1920. - Vol. 53, N 5. - P. 320-339.


13. Cyclical variation in paroxysmal supraventricular tachycardia in women / G.M. Rosano [et al.] // Lancet Lond. Engl. - 1996. - Vol. 347, N 9004. - P. 786-788.


14. Dobrokachestvennie aritmii pozdnego podrostkovogo vozrasta y zdorovih lic, kak mejdisciplinarnaya problema / I.A. Stepanenko [i dr.] // Medline.ru. Ros. biomedic. jyrn. - 2017. - T. 18, ? st. 40. - S. 591-608.


15. Usefulness of ventricular premature complexes to predict coronary heart disease events and mortality (from the Atherosclerosis Risk In Communities cohort) / M.W. Massing [et al.] // Am. J. Cardiol. - 2006. - Vol. 98, N 12. - P. 1609-1612.


16. Premature Ventricular Complexes on Screening Electrocardiogram and Risk of Ischemic Stroke / S.K. Agarwal [et al.] // Stroke J. Cereb. Circ. - 2015. - Vol. 46, N 5. - P. 1365-1367.


17. Premature cardiac contractions and risk of incident ischemic stroke / U. Ofoma [et al.] // J. Am. Heart Assoc. - 2012. - Vol. 1, N 5. - P. e002519.


18. Ventricular Ectopy as a Predictor of Heart Failure and Death / J.W. Dukes [et al.] // J. Am. Coll. Cardiol. - 2015. - Vol. 66, N 2. - P. 101-109.


19. Meta-analysis of ventricular premature complexes and their relation to cardiac mortality in general populations / F. Ataklte [et al.] // Am. J. Cardiol. - 2013. - Vol. 112, N 8. - P. 1263-1270.


20. The prognostic significance of premature ventricular complexes in adults without clinically apparent heart disease: a meta-analysis and systematic review / V. Lee [et al.] // Heart Br. Card. Soc. - 2012. - Vol. 98, N 17. - P. 1290-1298.


21. Prognostic significance of PVCs and resting heart rate / G. Engel [et al.] // Ann. Noninvasive Electrocardiol. Off. J. Int. Soc. Holter Noninvasive Electrocardiol. Inc. - 2007. - Vol. 12, N 2. - P. 121-129.


22. Bikkina, M. Asymptomatic ventricular arrhythmias and mortality risk in subjects with left ventricular hypertrophy / M. Bikkina, M.G. Larson, D. Levy // J. Am. Coll. Cardiol. - 1993. - Vol. 22, N 4. - P. 1111-1116.


23. Prognostic significance of ventricular arrhythmias post-myocardial infarction / P. Khairy [et al.] // Can. J. Cardiol. - 2003. - Vol. 19, N 12. - P. 1393-1404.


24. Prognostic Significance of Premature Atrial Complexes Burden in Prediction of Long-Term Outcome / C.-Y. Lin [et al.] // J. Am. Heart Assoc. - 2015. - Vol. 4, N 9. - P. e002192.


25. Chastota i harakter naryshenii serdechnogo ritma po dannim sytochnogo monitorirovaniya y zdorovih voennoslyjashih molodogo vozrasta / A.N. Kychmin [i dr.] // Voen.-med. jyrn. - 2010. - ? 4. - S. 13-19.


26. Narysheniya ritma i provodimosti serdca y zdorovih lic / V.M. Tihonenko [i dr.] // Vestn Aritmologii. - 2018. - ? 91. - S. 11-20.


27. Goliys, O.A. Harakter aritmii i zakonomernosti sytochnoi dinamiki serdechnogo ritma y lic molodogo vozrasta : avtoreferat dis. ? kand. med. nayk : 14.01.05 / O.A. Goliys. - SPb : [Mesto zashiti: Voenn.-med. akad. im. S.M. Kirova], 2010. - 16 s.


28. An observational study on the effect of premature ventricular complex burden on long-term outcome / C.-Y. Lin [et al.] // Medicine (Baltimore). - 2017. - Vol. 96, N 1.


29. Sposob skriningovoi diagnostiki displazii soedinitelnoi tkani y detei / V.G. Arsentev [i dr.] // Ros Med Jyrn. - 2014. - ? 3. - S. 26-29.


30. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology // Eur. Heart J. - 1996. - Vol. 17, N 3. - P. 354-381.


31. Earliest cardiac toxicity induced by iron overload selectively inhibits electrical conduction / K.A. Schwartz [et al.] // J. Appl. Physiol. Bethesda Md 1985. - 2002. - Vol. 93, N 2. - P. 746-751.


32. Fan, L. Electrophysiological changes of autonomic cells in left ventricular outflow tract in guinea pigs with iron deficiency anemia complicated with chronic heart failure / L. Fan, L.-F. Chen, J. Fan // Asian Pac. J. Trop. Med. - 2017. - Vol. 10, N 12. - P. 1197-1200.


33. Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease / P.N. Hopkins [et al.] // Arterioscler. Thromb. Vasc. Biol. - 1996. - Vol. 16, N 2. - P. 250-255.


34. Schwertner, H.A. Association of low serum concentration of bilirubin with increased risk of coronary artery disease / H.A. Schwertner, W.G. Jackson, G. Tolan // Clin. Chem. - 1994. - Vol. 40, N 1. - P. 18-23.


35. The effect of Gilbert?s syndrome on the dispersions of QT interval and P-wave: an observational study / E. Cüre [et al.] // Anadolu Kardiyol. Derg. AKD Anatol. J. Cardiol. - 2013. - Vol. 13, N 6. - P. 559-565.

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