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ООО "ИЦ КОМКОН".




Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

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«
Vol. 9, Art. 9 (pp. 90-100)    |    apr 2008       
»

The long-term neurochemical effects of prenatal exposure to selective M-and N-cholinolytics.



Brief summary

Results of researches showed that prenatal exposure of M-and N-cholinolytics to pregnant female rats at 9-19 days of pregnancy could produce the long-term neurochemical changes in development of brain neurotransmitter systems at 2 month old rats progenies. Significant decrease in DA, 5-HT, NA concentrations and changes of their metabolites level were marked. Prenatal exposure to N-cholinolytic, gangleron to pregnant females at 9-11 and 12-14 gestation days exerted more significant long-term effect on neurotransmitter development, which leads to reduction of transmitter activity in the hippocamp and hypothalamus in comparison with a control progeny. These results indicate that M- and N-cholinolytics exposure during the "critical periods" of prenatal development (9-11 and 12-14 gestational days) results in long-term changes in development of neurotransmitter systems in the brain structure participating in regulation of behavioral and neuroendocrinal functions at rat male offspring.


Key words

cholinolytics, prenatal exposure, neurotransmitters, rat progeny, long-term effects.





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