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Информационное партнерство

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Vol. 9, Art. 21 (pp. 240-254)    |    2008       

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Brief summary

Radiation therapy and chemotherapy (RCT) by genotoxic cytostatic drugs are widely used in oncology. In this study we demonstrate that RCT induces alteration in mtDNA copy number in peripheral blood of cancer patients. Moreover, AFLP analysis of short tandem repeat loci has shown that after RCT course, deletions and insertions appeared in STR loci. These deletions and insertions, in most cases appear in patients with significant dynamic of mtDNA copy number changing.


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Reference list

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