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Федеральное государственное бюджетное учреждение науки
Институт теоретической и экспериментальной биофизики
Российской академии наук


ООО "ИЦ КОМКОН"

Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

ISSN 1999-6314


Фундаментальные исследования • Биофизика

Том: 9
Статья: « 20 »
Страницы:. 196-240
Опубликована в журнале: ноябрь 2008 г.

English version

Дифференцировка клеток обратима: соматические научились превращать в плюрипотентные стволовые

Бочарова Л.С.

Институт теоретической и экспериментальной биофизики РАН
Пущино, Московская область


Резюме
Серьезный прорыв в области клеточных технологий сделал возможным превращение различных соматических клеток в индуцированные плюрипотентные стволовые (iPS) клетки. По свойствам они аналогичны клеткам внутренней клеточной массы бластоцисты (ICM) и эмбриональным стволовым (ES) клеткам. iPS клетки активно пролиферируют in vitro, сохраняя свойства недифференцированных клеток, и в то же время способны превращаться в любые клетки организма. В обзоре анализируются свойства iPS клеток мышей и человека, методы их получения, молекулярные механизмы трансформации специализированных клеток, возможность их применении в медицинской практике.


Ключевые слова
дифференцировка, плюрипотентность, индукторы, эпигенетические изменения, клеточная терапия, источники клеток



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