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Vol. 24, Art. 40 (pp. 528-541)    |    2023       

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Experimental and mathematical modeling of the effects of regulated doses of ionizing radiation on the brain

Fedorov V.P.1, Ushakov I.B.2,3, Kholodov O.M.1

1Voronezh State Academy of Sports
2State Research Center - Burnasyan Federal Medical Biophysical Center of the FMBA of Russia
3Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia

Brief summary

In the identified cases of radiation changes in normal doses, a significant increase in the states of the nervous system was observed, which were difficult to succumb to and persisted throughout life. High medical and social detection of health disorders induced by ionizing radiation, detection of morphological changes in the brain. However, classical neuromorphological procedures do not make it possible to identify various factors associated with a radiation catastrophe, a priority impairment of brain function. It is quite obvious that it is necessary to use methods of experimental and mathematical modeling on laboratory animals to study radiation pathology of the brain, followed by extrapolation of the results to humans. In this work, it was established that the response of neurons during γ-irradiation depended on the exposure dose and on the elapsed time. Ionizing radiation evoked a response in most indicators of the functional state of nerve cells, but over time, the damage was restored. At the same time, some damages were not repaired and, accumulating, caused stochastic extrema in certain periods of the experiment. Such fluctuations in the structural and functional state of nerve cells indicated their instability and intensity of functioning.


Key words

ionizing radiation; brain; neuropsychiatric disorders; experimental and mathematical modeling

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