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Vol. 23, Art. 41 (pp. 694-704)    |    2022       

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The efficiency of the use of pre-pro-symbiotics in the perio-operative period in patients with colorectal cancer (review of the literature).

Ten O.A., Zakharenko A.A., Suvorov A.N., Belyaev M.A., Alekhina G.G.

1 First Pavlov State Medical University of St. Peterburg.

2 Federal State Budgetary Scientific Institution. Institute of Experimental Medicine.

Brief summary

To date, the main treatment for colorectal cancer is surgical resection of the tumor, preceded or followed by chemotherapy and radiation therapy, depending on the stage of the disease. Despite the fact that a number of preoperative preventive measures are taken to minimize the risks of postoperative infections and complications, they are not sufficient. For a long time, mechanical bowel cleansing has been used in combination with the prophylactic use of antibiotics. However, there is controversy regarding the effectiveness of this method, since it leads to a number of complications such as gastrointestinal disorders, metabolic disorders, etc. Modulation of the intestinal microflora with probiotics seems to be an effective method for reducing complications in surgical patients. Probiotics can maintain the balance of the microbiome after surgery by maintaining the integrity of the intestinal mucosa and reducing bacterial translocation. This review aims to evaluate the efficacy of pre-pro- and symbiotics in colorectal cancer surgery.


Key words

colorectal cancer, probiotics, colorectal cancer surgery, postoperative complications in colorectal cancer, colon microflora after surgical treatment.

Reference list

1. Stewart, B.; Wild, C.P. (Eds.) World Cancer Report 2014; International Agency for Research on Cancer (IARC): Lyon, France, 2014.


2. Brody, H. Colorectal cancer. Nature. 2015; 521(7551): S1.


3. WHO Surgical Site Infection Guidelines. Web Appendix 6. Summary of a Systemic Review on Mechanical Bowel Preparation and the Use of Oral Antibiotics. Available online: https://www.who.int/gpsc/appendix6.pdf?ua=1 (accessed on 23 March 2020).


4. Reddy, B.S.; Gatt, M.; Sowdi, R.; MacFie, J. Surgical manipulation of the large intestine increases bacterial translocation in patients un-dergoing elective colorectal surgery. Colorectal Dis. Off. J. Assoc. Coloproctol. Great Br. Irel. 2006, 8, 596-600.


5. Saadia, R.; Schein, M.; Macfarlane, C.; Boffard, K.D. Gut barrier function and the surgeon. Br. J. Surg. 1990, 77, 487-492.


6. Espín-Basany, E.; Solís-Peña, A.; Pellino, G.; Kreisler, E.; Fraccalvieri, D.; Muinelo-Lorenzo, M.; Maseda-Díaz, O.; García-González, J.M.; Santamaría-Olabarrieta, M.; Codina-Cazador, A.; et al. Preoperative oral antibiotics and surgical-site infections in colon surgery (ORALEV): A multicentre, single-blind, pragmatic, randomised controlled trial. Lancet Gastroenterol. Hepatol. 2020, 5, 729-738. Fijan, S. Microorganisms with Claimed Probiotic Properties: An Overview of Recent Literature. Int. J. Environ. Res. Public Health 2014, 11, 4745-4767.


7. Bajramagic, S.; Hodzic, E.; Mulabdic, A.; Holjan, S.; Smajlovic, S.V.; Rovcanin, A. Usage of probiotics and its clinical significance at surgically treated patients suffering from colorectal carcinoma. Med. Arch. 2019, 73, 316-320.


8. Wei, D.; Heus, P.; Van De Wetering, F.T.; Van Tienhoven, G.; Verleye, L.; Scholten, R.J. Probiotics for the prevention or treatment of chemotherapy- or radiotherapy-related diarrhoea in people with cancer. Cochrane Database Syst. Rev. 2018, 8, CD008831.


9. Torres, J.; Ellul, P.; Langhorst, J.; Mikocka-Walus, A.; Barreiro-de, A.M.; Basnayake, C.; Sheng Ding, N.; Gilardi, D.; Katsanos, K.; Moser, G.; et al. European Crohn?s and Colitis Organisation Topical Review on Complementary Medicine and Psychotherapy in Inflammatory Bowel Disease. J. Crohns Colitis. 2019, 27, 673-685. Yu, A.Q.; Li, L. The Potential Role of Probiotics in Cancer Prevention and Treatment. Nutr. Cancer 2016, 68, 535-544.


10. Gianotti, L.; Morelli, L.; Galbiati, F.; Rocchetti, S.; Coppola, S.; Beneduce, A.; Gilardini, C.; Zonenschain, D.; Nespoli, A.; Braga, M. A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients. World J. Gastroenterol. 2010, 16, 167.


11. Aisu N, Tanimura S, Yamashita Y, et al. Impact of perioperative probiotic treatment for surgical site infections in patients with colorectal cancer. Exp Ther Med. 2015;10(3):966-972.


12. Kotzampassi K, Stavrou G, Damoraki G, et al. A four-probiotics regimen reduces postoperative complications after colorectal surgery: a randomized, double-blind, placebo-controlled study. World J Surg. 2015;39(11):2776-2783.


13. Yang Y, Xia Y, Chen H, et al. The effect of perioperative probiotics treatment for colorectal cancer: shortterm outcomes of a randomized controlled trial. Oncotarget. 2016;7(7):8432-8440.


14. Liu ZH, Huang MJ, Zhang XW, et al. The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoperative infectious complications after colorectal cancer surgery: a doublecenter and double-blind randomized clinical trial. Am J Clin Nutr. 2013;97(1):117-126.


15. Mizuta M, Endo I, Yamamoto S, et al. Perioperative supplementation with bifidobacteria improves postoperative nutritional recovery, inflammatory response, and fecal microbiota in patients undergoing colorectal surgery: a prospective, randomized clinical trial. Biosci micribiote food health.2016;35(2):77-87.


16. Salem Bajramagic1 , Edin Hodzic1 , Adi Mulabdic et al. Usage of Probiotics and its Clinical Significance at Surgically Treated Patients Sufferig from Colorectal Carcinoma. Med Aarch. 2019; 73(5): 316-320.


17. Sadahiro S, Suzuki T, Tanaka A, et al. Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: prospective randomized trial. Surgery. 2014;155(3):493-503.


18. Liu, Z.; Qin, H.; Yang, Z.; Xia, Y.; Liu, W.; Yang, J.; Jiang, Y.; Zhang, H.; Yang, Z.; Wang, Y.; et al. Randomised clinical trial: The effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery?A double-blind study. Aliment. Pharmacol. Ther. 2011, 33, 50-63.


19. Mangell, P.; Henrik, T.; Syk, I.; Ahrné, S.; Molin, G.; Olsson, C.; Jeppsson, B. Lactobacillus plantarum 299v does not reduce enteric bacteria or bacterial translocation in patients undergoing colon resection. Dig. Dis. Sci. 2012, 57, 1915-1924.


20. Zhang, J.W.; Du, P.; Yang, B.-R.; Gao, J.; Fang, W.-J.; Ying, C.-M. Preoperative Probiotics Decrease Postoperative Infectious Complications of Colorectal Cancer. Am. J. Med. Sci. 2012, 343, 199-205.


21. Louise Pitsillides, Gianluca Pellino, Paris Tekkis et al. The effect of perioperative administration of probiotics on colorectal cancer surgery outcomes. Nutrients. 2021, 13, 1451-1462.


22. Kakaei F, Shahrasbi M, Kermani TA, et al. Assessment of probiotic effects on colorectal surgery complications: a double blinded, randomized clinical trial. Biomed Res Ther. 2019;6:3067-3072.


23. Liyana Zaharuddin, Norfilza Mohd Mokhtar, Khairul Najmi Muhammad Nawawi, Raja Affendi Raja Ali. A randomized double-blind placebocontrolled trial of probiotics in post-surgical colorectal cancer. BMC Gastroenterology. 2019, 19, 131-138.


24. Krebs B. Prebiotic and synbiotic treatment before colorectal surgery?randomised double blind trial. Coll Antropol. 2016;40(1):35-40.