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Vol. 23, Art. 4 (pp. 57-74)    |    2022       

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Pathophysiological bases for prediction of human resistance to hypoxia in mountains (literature review)

Shiryaeva A.I., Fateev I.V., Kuzmin A.A., Ovchinnikova A.S., Vetryakov O.V., Shkarupa A.V.

State scientific-research test Institute of military medicine of Defense Ministry of the Russian Federation
Kirov Military Medical Academy of Russian Federation Defense Ministry, Saint Petersburg, Russia.

Brief summary

The number of professionals performing their work in the mountains, as well as people involved in sports and active recreation at high altitudes, is constantly growing, which undoubtedly increases the relevance of the development and implementation of medical measures for preliminary assessment of the human body's resistance to adverse factors in high mountains and predicting possible risks to human health. In this regard, we analyzed the modern literature data on the effect of mountain hypoxia on the functional state of a person, considered the main pathogenetic mechanisms of compensatory reactions of the respiratory, cardiovascular and nervous systems to hypoxemia that occurs in conditions of a low oxygen content in the inhaled air. As a result, the need for a comprehensive study of the functioning and response of these body systems was shown for the development of prognostic methods of human resistance to hypoxia.


Key words

mountain hypoxia, resistance to hypoxia, acute mountain sickness, hypoxic pulmonary vasoconstriction, HVR, VE, PIO2, SaO2.

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