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Vol. 23, Art. 39 (pp. 668-678)    |    2022       

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Integral evaluation of the results of toxicological experimental studies using the desirability function

Verveda A.B., Lianginen L.V., Vikharev Y.B. 1

Federal State Budgetary Institution S.N. Golikov Scientific and Clinical Center of the Federal Medical and Biological Agency, St. Petersburg, Russia

Brief summary

The study was conducted in order to substantiate the feasibility of using special methods to obtain integral characteristics of a toxicological experiment. The Harrington desirability function is described as the main method. It is shown, that the presented method of mathematical and statistical processing makes it possible to obtain individual and group integral indicators of the state of the organism of laboratory animals, which contributes to improving the quality of interpretation of the information received. The use of the Harrington function is an additional tool that allows making informed decisions based on the results of toxicological experimental studies.


Key words

toxicological studies, function of desirability, laboratory animals, integral assessment, individual sensitivity

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