МЕДЛАЙН.РУ
Содержание журнала

Архив

Редакция
Учредители

Федеральное государственное бюджетное учреждение науки
Институт теоретической и экспериментальной биофизики
Российской академии наук


ООО "ИЦ КОМКОН"

Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

ISSN 1999-6314


Клиническая медицина » Хирургия • Онкология, лучевая терапия

Том: 23
Статья: « 34 »
Страницы:. 608-623
Опубликована в журнале: 15 сентября 2022 г.

English version

Внутрибрюшная химиотерапия при раке желудка (обзор литературы)

Зайцев Д.А., Натха А.С., Беляев М.А., Хамид А.Х., Вовин К.Н., Купенская Т.В., Вервекин И.В., Свечкова А.А., Захаренко А.А.

ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» МЗ РФ


Резюме
Рак желудка является третьим в мире в структуре смертности от онкологических заболеваний и часто характеризуется перитонеальной диссеминацией, как единственным проявлением метастатического процесса. При выявлении карциноматоза брюшины медиана выживаемости у таких пациентов крайне мала, а системное химиотерапевтическое лечение малоэффективно. Внутрибрюшная химиотерапия давно доказала свою эффективность в лечении определенных заболеваний с распространением по брюшине. Все чаще проводятся клинические исследования об эффективности регионарных методик при карциноматозе брюшины у пациентов с диагнозом рака желудка. Основными методиками являются различные варианты гипертермической внутрибрюшной химиоперфузии (открытый, закрытый и лапароскопический HIPEC), а также сравнительно новая методика аэрозольной внутрибрюшной химиотерапии под давлением (PIPAC). Однако показания к применению различных методик внутрибрюшной химиотерапии до сих пор не регламентирована, а эффективность их применения в конкретных клинических случаях требует дальнейшего изучения.


Ключевые слова
регионарная химиотерапия, внутрибрюшная химиотерапия, аэрозольная химиотерапия, рак желудка, карциноматоз, перитонеальная диссеминация, HIPEC, PIPAC.



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Список литературы

1. Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries / CA Cancer J Clin. 2018. Vol. 68(6). P. 394-424. doi: 10.3322/caac.21492


2. Thomassen I., van Getsel Y.R., van Ramshorst B., Luyer M.D., Bosscha K., Neinhuijs S.W., Lemmens V.E., de Hingh I.H. Peritoneal Carcinomatosis of Gastric Origin: A Population-Based Study on Incidence, Survival and Risk Factors / Int J Cancer. 2014. Vol. 134(3). P. 622-628. doi: 10.1002/ijc.28373


3. Gamboa A.C., Winer J.H. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for gastric cancer / Cancers. 2019. Vol. 11. P. 1662. doi: 10.3390/cancers11111662


4. Macrì A., Morabito F. The use of intraperitoneal chemotherapy for gastric malignancies / Expert Rev Anticancer Ther. 2019. Vol. 19. P. 879-88. doi: 10.1080/14737140.2019.1671189


5. Manzanedo I, Pereira F, Rihuete Caro C, Pérez-Viejo E., Serrano Á., Gutiérrez Calvo A., Regueira F.M., Casado-Adam Á., Cascales-Campos P.A., Arteaga X., García-Fadrique A., Gómez Sanz R., López García A., Zozaya G., Arjona Á., Gil Martínez J. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Gastric Cancer with Peritoneal Carcinomatosis: Multicenter Study of Spanish Group of Peritoneal Oncologic Surgery (GECOP) / Ann Surg Oncol. 2019. Vol. 26. P. 2615-2621. doi: 10.1245/s10434-019-07450-4.


6. Rihuete Caro C., Manzanedo I., Pereira F., Carrion-Alvarez L., Serrano Á., Pérez-Viejo E. Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with gastric cancer and peritoneal carcinomatosis / Eur J Surg Oncol. 2018. Vol. 44. P. 1805-1810. doi: 10.1016/j.ejso.2018.06.036.


7. Oh S.Y., Kwon H.C., Lee S., Lee D.M., Yoo H.S., Kim S.H., Jang J.S., Kim M.C., Jeong J.S., Kim H.J. A Phase II Study of Oxaliplatin with Low-dose Leucovorin and Bolus and Continuous Infusion 5-Fluorouracil (Modified FOLFOX-4) for Gastric Cancer Patients with Malignant Ascites / Jpn. J. Clin. Oncol. 2007. Vol. 37. P. 930-935. doi: 10.1093/jjco/hym131


8. Shirao K., Boku N., Yamada Y., Yamaguchi K., Doi T., Goto M., Nasu J., Denda T., Hamamoto Y., Takashima A., Fukuda H., Ohtsu A. Randomized Phase III Study of 5-Fluorouracil Continuous Infusion vs. Sequential Methotrexate and 5-Fluorouracil Therapy in Far Advanced Gastric Cancer with Peritoneal Metastasis (JCOG0106) / Jpn. J. Clin. Oncol. 2013. Vol. 43. P. 972-980. doi: 10.1093/jjco/hyt114


9. Yamao T., Shimada Y., Shirao K., Ohtsu A., Ikeda N., Hyodo I., Saito H., Iwase H., Tamura T., Yamamoto S., Yoshida S. Phase II Study of Sequential Methotrexate and 5-Fluorouracil Chemotherapy against Peritoneally Disseminated Gastric Cancer with Malignant Ascites: A Report from the Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group, JCOG 9603 Trial / Jpn. J. Clin. Oncol. 2004. Vol. 34. P. 316-322. doi: 10.1093/jjco/hyh063


10. Muro K., Chung H.C., Shankaran V., Geva R., Catenacci D., Gupta S., Eder J.P., Golan T., Le D.T., Burtness B., McRee A.J., Lin C.C., Pathiraja K., Lunceford J., Emancipator K., Juco J., Koshiji M., Bang Y.J. Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): A multicentre, open-label, phase 1b trial / Lancet Oncol. 2016. Vol. 17. P. 717-726. doi: 10.1016/S1470-2045(16)00175-3


11. Van Cutsem E., Moiseyenko V.M., Tjulandin S., Majlis A., Constenla M., Boni C., Rodrigues A., Fodor M., Chao Y., Voznyi E., Risse M.L., Ajani J.A. Phase III Study of Docetaxel and Cisplatin plus Fluorouracil Compared with Cisplatin and Fluorouracil as First-Line Therapy for Advanced Gastric Cancer: A Report of the V325 Study Group / J. Clin. Oncol. 2006. Vol. 24. P. 4991-4997. doi: 10.1200/JCO.2006.06.8429


12. Fujitani K., Yang H.K., Mizusawa J., Kim Y.W., Terashima M., Han S.U., Iwasaki Y., Hyung W.J., Takagane A., Park D.J., Yoshikawa T., Hahn S., Nakamura K., Park C.H., Kurokawa Y., Bang Y.J., Park B.J., Sasako M., Tsujinaka T. Gastrectomy plus chemotherapy versus chemotherapy alone for advanced gastric cancer with a single non-curable factor (REGATTA): A phase 3, randomised controlled trial / Lancet Oncol. 2016. Vol. 17. P. 309-318. doi: 10.1016/S1470-2045(15)00553-7


13. Yan T.D., Welch L., Black D., Sugarbaker P.H. A systematic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for diffuse malignancy peritoneal mesothelioma / Ann Oncol. 2007. Vol. 18. P. 827-834. doi: 10.1093/annonc/mdl428


14. Verwaal V.J., Bruin S., Boot H., van Slooten G., van Tinteren H. 8-year follow-up of randomized trial: cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer / Ann Surg Oncol. 2008. Vol. 15. P. 2426-2432. doi: 10.1245/s10434-008-9966-2


15. Sugarbaker P.H. New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome? / Lancet Oncol. 2006. Vol. 7. P. 69-76. doi: 10.1016/S1470-2045(05)70539-8


16. Chu D.Z., Lang N.P., Thompson C., Osteen P.K., Westbrook K.C. Peritoneal Carcinomatosis in Nongynecologic Malignancy. A Prospective Study of Prognostic Factors / Cancer. 1989. Vol. 63. P. 364-367. doi: 10.1002/1097-0142(19890115)63:2<364::aid-cncr2820630228>3.0.co;2-v


17. Fujimoto S., Shrestha R.D., Kokubun M., Ohta M., Takahashi M., Kobayashi K., Kiuchi S., Okui K., Miyoshi T., Arimizu N. Intraperitoneal Hyperthermic Perfusion Combined With Surgery Effective for Gastric Cancer Patients With Peritoneal Seeding / Ann Surg. 1988. Vol. 208(1). P. 36-41. doi: 10.1097/00000658-198807000-00005


18. Yarema R., Mielko J., Fetsych T., Ohorchak M., Skorzewska M., Rawicz-Pruszyński K., Mashukov A., Maksimovsky V., Jastrzębski T., Polkowski W., Gyrya P., Kovalchuk Y., Safiyan V., Karelin I., Kopetskiy V., Kolesnik O., Kondratskiy Y., Paskonis M. Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Combined Treatment of Locally Advanced and Intraperitoneally Disseminated Gastric Cancer: A Retrospective Cooperative Central Eastern European Study / Cancer Med. 2019. Vol. 8. P. 2877-2885. doi: 10.1002/ cam4.2204


19. Beeharry M.K., Zhu Z.L., Liu W.T., Yao X.X., Yan M., Zhu Z.G. Prophylactic HIPEC With Radical D2 Gastrectomy Improves Survival and Peritoneal Recurrence Rates for Locally Advanced Gastric Cancer: Personal Experience from a Randomized Case Control Study / BMC Cancer. 2019. Vol. 19. P. 932. doi: 10.1186/s12885-019-6125-z


20. Feingold P.L., Kwong M.L., Davis J.L., Rudolf U. Adjuvant Intraperitoneal Chemotherapy for the Treatment of Gastric Cancer at Risk for Peritoneal Carcinomatosis: A Systematic Review / J Surg Oncol. 2017. Vol. 115(2). P. 192-201. doi: 10.1002/jso.24476


21. Desiderio J., Chao J., Melstrom L., Warner S., Tozzi F., Fong Y., Parisi A., Woo Y. The 30-Year Experience-A Meta-Analysis of Randomised and High-Quality non Randomised Studies of Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Gastric Cancer / Eur J Cancer. 2017. Vol. 79. P. 1-14. doi: 10.1016/ j.ejca.2017.03.030


22. Glehen O., Passot G., Villeneuve L., Vaudoyer D., Bin-Dorel S., Boschetti G., Piaton E., Garofalo A. GASTRICHIP: D2 Resection and Hyperthermic Intraperitoneal Chemotherapy in Locally Advanced Gastric Carcinoma: A Randomized and Multicenter Phase III Study / BMC Cancer. 2014. Vol. 14. P.183. doi: 10.1186/1471- 2407-14-183


23. Götze T.O., Piso P., Lorenzen S., Bankstahl U.S., Pauligk C., Elshafei M., Amato G., Reim D., Bechstein W.O., Königsrainer A., Mönig S.P., Rau B., Schwarzbach M., Al-Batran S.E. Preventive HIPEC in Combination With Perioperative FLOT Versus FLOT Alone for Resectable Diffuse Type Gastric and Gastroesophageal Junction Type II/III Adenocarcinoma - the Phase III "PREVENT"- (FLOT9) Trial of the AIO /CAOGI /ACO / BMC Cancer. 2021. Vol. 21(1). P. 1158. doi: 10.1186/ s12885-021-08872-8


24. Yonemura Y., Ishibashi H., Hirano M., Mizumoto A., Takeshita K., Noguchi K., Takao N., Ichinose M., Liu Y., Li Y. Effects of Neoadjuvant Laparoscopic Hyperthermic Intraperitoneal Chemotherapy and Neoadjuvant Intraperitoneal/Systemic Chemotherapy on Peritoneal Metastases from Gastric Cancer / Ann Surg Oncol. 2017. Vol. 24. P. 478-485. doi: 10.1245/s10434-016-5487-6


25. Badgwell B., Ikoma N., Murphy M.B., Wang X., Estrella J., Roy-Chowdhuri S., Das P., Minsky B.D., Lano E., Song S., Mansfield P., Ajani J. A Phase II Trial of Cytoreduction, Gastrectomy, and Hyperthermic Intraperitoneal Perfusion With Chemotherapy for Patients With Gastric Cancer and Carcinomatosis or Positive Cytology / Ann Surg Oncol. 2021. Vol. 28(1). P. 258-264. doi: 10.1245/s10434-020-08739-5


26. Yang X.J., Huang C.Q., Suo T., Mei L.J., Yang G.L., Cheng F.L., Zhou Y.F., Xiong B., Yonemura Y., Li Y. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Improves Survival of Patients with Peritoneal Carcinomatosis from Gastric Cancer: Final Results of a Phase III Randomized Clinical Trial / Ann. Surg. Oncol. 2011. Vol. 18. P. 1575-1581. doi: 10.1245/s10434-011-1631-5


27. Rudloff U., Langan R.C., Mullinax J.E., Beane J.D., Steinberg S.M., Beresnev T., Webb C.C., Walker M., Toomey M.A., Schrump D., Pandalai P., Stojadinovic A., Avital I. Impact of maximal cytoreductive surgery plus regional heated intraperitoneal chemotherapy (HIPEC) on outcome of patients with peritoneal carcinomatosis of gastric origin: Results of the GYMSSA trial: Gastric Cancer Multimodal Therapy / J. Surg. Oncol. 2014. Vol. 110. P. 275-284. doi: 10.1002/jso.23633


28. Glehen O., Gilly F.N., Arvieux C., Cotte E., Boutitie F., Mansvelt B., Bereder J.M., Lorimier G., Quenet F., Elias D. Peritoneal carcinomatosis from gastric cancer: a multi-institutional study of 159 patients treated by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy / Ann Surg Oncol. 2010. Vol. 17. P. 2370-2377. doi: 10.1245/s10434-010-1039-7


29. Rau B., Brandl A., Piso P., Pelz J., Busch P., Demtröder C., Schüle S., Schlitt H.J., Roitman M., Tepel J., Sulkowski U., Uzunoglu F., Hünerbein M., Hörbelt R., Ströhlein M., Beckert S., Königsrainer I., Königsrainer A. Peritoneal metastasis in gastric cancer: Results from the German database / Gastric Cancer. 2020. Vol. 23. P. 11-22. doi: 10.1007/s10120-019-00978-0


30. Bonnot P.E., Piessen G., Kepenekian V., Decullier E., Pocard M., Meunier B., Bereder J.M., Abboud K., Marchal F., Quenet F., Goere D., Msika S., Arvieux C., Pirro N., Wernert R., Rat P., Gagnière J., Lefevre J.H., Courvoisier T., Kianmanesh R., Vaudoyer D., Rivoire M., Meeus P., Passot G., Glehen O. Cytoreductive Surgery with or without Hyperthermic Intraperitoneal Chemotherapy for Gastric Cancer with Peritoneal Metastases (CYTO-CHIP study): A Propensity Score Analysis / J. Clin. Oncol. 2019. Vol. 37. P. 2028-2040. doi: 10.1200/JCO.18.01688


31. Facchiano E., Scaringi S., Kianmanesh R., Sabate J.M., Castel B., Flamant Y., Coffin B., Msika S. Laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of malignant ascites secondary to unresectable peritoneal carcinomatosis from advanced gastric cancer / Eur J Surg Oncol. 2008. Vol. 34. P. 154-158. doi: 10.1016/j.ejso.2007.05.015


32. Valle M., Van der Speeten K., Garofalo A. Laparoscopic hyperthermic intraperitoneal peroperative chemotherapy (HIPEC) in the management of refractory malignant ascites: A multi-institutional retrospective analysis in 52 patients: Laparoscopic HIPEC Is a Safe and Effective / J Surg Oncol. 2009. Vol. 100. P. 331-334. doi: 10.1002/jso.21321


33. Facchiano E., Risio D., Kianmanesh R., Msika S. Laparoscopic Hyperthermic Intraperitoneal Chemotherapy: Indications, Aims, and Results: A Systematic Review of the Literature / Ann Surg Oncol. 2012. Vol. 19. P. 2946-2950. doi: 10.1245/s10434-012-2360-0


34. Solaß W., Hetzel A., Nadiradze G., Sagynaliev E., Reymond M.A. Description of a novel approach for intraperitoneal drug delivery and the related device / Surg Endosc. 2012. Vol. 26. P. 1849-1855. doi: 10.1007/s00464-012-2148-0


35. Solass W., Kerb R., Mürdter T., Giger-Pabst U., Strumberg D., Tempfer C., Zieren J., Schwab M., Reymond M.A. Intraperitoneal Chemotherapy of Peritoneal Carcinomatosis Using Pressurized Aerosol as an Alternative to Liquid Solution: First Evidence for Efficacy / Ann Surg Oncol. 2014. Vol. 21. P. 553-559. doi: 10.1245/s10434-013-3213-1


36. Nadiradze G., Giger-Pabst U., Zieren J., Strumberg D., Solass W., Reymond M.A. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) With Low-Dose Cisplatin and Doxorubicin in Gastric Peritoneal Metastasis / J Gastrointest Surg. 2016. Vol. 20. P. 367-373. doi: 10.1007/s11605-015-2995-9.


37. Alyami M., Bonnot P.E., Mercier F., Laplace N., Villeneuve L., Passot G., Bakrin N., Kepenekian V., Glehen O. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) for Unresectable Peritoneal Metastasis from Gastric Cancer / Eur J Surg Oncol. 2021. Vol. 47(1). P. 123-127. doi: 10.1016/j.ejso.2020.05.021


38. Di Giorgio A., Schena C.A., El Halabieh M.A., Abatini C., Vita E., Strippoli A., Inzani F., Rodolfino E., Romanò B., Pacelli F., Rotolo S. Systemic Chemotherapy and Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): A Bidirectional Approach for Gastric Cancer Peritoneal Metastasis / Surg Oncol/ 2020. Vol. 34. P. 270-275. doi: 10.1016/j.suronc.2020.05.006


39. Khomyakov V., Ryabov A., Ivanov A., Bolotina L., Utkina A., Volchenko N., Kaprin A. Bidirectional chemotherapy in gastric cancer with peritoneal metastasis combining intravenous XELOX with intraperitoneal chemotherapy with low-dose cisplatin and Doxorubicin administered as a pressurized aerosol: An open-label, Phase-2 study (PIPAC-GA2) / Pleura Peritoneum. 2016. Vol. 1. P. 159-166. doi: 10.1515/pp-2016-0017


40. Garg P.K., Jara M., Alberto M., Rau B. The Role of Pressurized Intraperitoneal Aerosol Chemotherapy in the Management of Gastric Cancer: A Systematic Review / Pleura Peritoneum. 2019. Vol. 4(1):20180127. doi: 10.1515/pp-2018-0127


41. Eveno C., Jouvin I., Pocard M. PIPAC EstoK 01: Pressurized Intraperitoneal Aerosol Chemotherapy With Cisplatin and Doxorubicin (PIPAC C/D) in Gastric Peritoneal Metastasis: A Randomized and Multicenter Phase II Study / Pleura Peritoneum. 2018. Vol. 3(2):20180116. doi: 10.1515/pp-2018-0116


42. Kim G., Tan H.L., Chen E., Teo S.C., Jang C.J.M., Ho J., Ang Y., Ngoi N.Y.L., Chee C.E., Lieske B., Shabbir A., Wang L.Z., So J.B.Y., Yong W.P. Study Protocol: Phase 1 Dose Escalating Study of Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) With Oxaliplatin in Peritoneal Metastasis / Pleura Peritoneum. 2018. Vol. 3(3):20180118. doi: 10.1515/pp-2018-0118


43. Dumont F., Senellart H., Pein F., Campion L., Glehen O., Goere D., Pocard M., Thibaudeau E. Phase I/ II Study of Oxaliplatin Dose Escalation via a Laparoscopic Approach Using Pressurized Aerosol Intraperitoneal Chemotherapy (PIPOX Trial) for Nonresectable Peritoneal Metastases of Digestive Cancers (Stomach, Small Bowel and Colorectal): Rationale and Design / Pleura Peritoneum. 2018. Vol 3(3):20180120. doi: 10.1515/pp-2018-0120


44. Struller F., Horvath P., Solass W., Weinreich F.J., Strumberg D., Kokkalis M.K., Fischer I., Meisner C., Königsrainer A., Reymond M.A. Feasibility, Efficacy and Safety of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) With Cisplatin and Doxorubicin in Patients With Gastric Cancer and Peritoneal Carcinomatosis: An Open-Label, Single-Arm, Phase II Clinical Trial (PIPAC-Ga01) / Ther Adv Med Oncol. 2019. Vol. 11:1758835919846402. doi: 10.1177/1758835919846402


45. Graversen M., Detlefsen S., Asmussen J., Mahdi B., Fristrup C., Pfeiffer P., Mortensen M.B. Treatment of peritoneal carcinomatosis with Pressurized Intraperitoneal Aerosol Chemotherapy PIPAC-OPC2 / Pleura Peritoneum. 2018. Vol. 3(2):20180108. doi: 10.1515/pp-2018-0108