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Vol. 22, Art. 10 (pp. 132-146)    |    2021       

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Dynamics of neurological symptoms in the treatment of alcohol dependence syndrome

Litvincev B.S.1, Konstantinov D.P.2, Ardashev M.V.2, Petrov A.D.2, Zharkova I.A.2, Fomichev A.V.1, Sosyukin A.E.1, Zatsepin E.P1, Malysheva E.V.1

The Federal State-Financed Institution Golikov Research Clinical Center of Toxicology under the Federal Medical Biological Agency (192019, Saint Petersburg, Russian Federation)
Saint Petersburg state budgetary institution of health City Narcological Hospital (199004, Saint Petersburg, Russian Federation)

Brief summary

The article substantiates the feasibility, as well as demonstrates the effectiveness and safety of neurometabolic therapy at an early stage of treatment of alcohol dependence syndrome. Dynamic observation of 40 male patients at the stage of early treatment of alcohol dependence was carried out. The average age of the surveyed persons was 41.5 - 6.9 years (from 23 to 59 years). Neurological examination was performed on the day of admission of the patient for treatment and on the day of discharge from the hospital after detoxification and antiabstinent therapy. Starting from the first day of hospitalization on the background of specific pharmacotherapy of mental disorders, all examined patients underwent neurometabolic therapy. Observation of patients allowed us to establish a clear positive dynamics of neurological symptoms - memory and attention improved in most patients, coordination disorders regressed statistically significantly (from 52.5% to 12.6%), and hemodynamic parameters stabilized. Neurometabolic therapy in the complex treatment of alcohol dependence syndrome has already shown its effectiveness and safety at an early stage.


Key words

narcology, alcoholism, alcohol dependence, neurology, neurometabolic therapy, neurological disorders, cognitive disorders.

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