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Vol. 21, Art. 93 (pp. 1196-1209)    |    2020       

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The effect of peptide preparation containing a fragment 4-10 of adrenocorticotropic hormone and delta sleep inducing peptide on he development offspring in the postnatal period

1Belyakova N.A., 2Bonitenko E.U., 3Lisitsky D.S., 1Gorbunova L.V.

1FSBUN IT FMBA Federal State Budgetary Institution of Science «Institute of toxicology of the Federal medical-biological agency»
192019, Sankt-Peterburg, ul. Behtereva, d.1, telefon/faks: (812) 365-06-80.

2FSBNU NII MT Federal State Budgetary Science Institution «Scentific institute of occupational medicine named after academician N.F. Izmerova»
105275, Moskva, pr. Budennogo, d.31

3 FSBEI HE StPSCPU Federal State Budgetary Educational Institution of Hight Education «Sant-Petersburg State Chemical and Pharmaceutical University»
197022, Sankt-Peterburg, ul. Prof. Popova, d.14

Brief summary

The aim of the study was to assess the effect of delta-sleep inducing peptide (DSIP) and an analogue of the ACTH4-10 fragment (FACTG) on the postnatal development of the offspring of female non-inbred rats. The study was carried out in two stages. At the first stage, female rats received peptide preparations for 2 weeks, after which they mated with intact males. At the second stage, the parameters of physical and sensory-motor development were investigated in the newborn offspring using standard methods, and also behavioral reactions were studied in the "cruciform maze" test. For a comprehensive assessment of the development of offspring in the postnatal period, indices of physical and sensory-motor development were used, and the index of harmony of development was calculated. It was found that peptide preparations containing DSIP and 4-10 ACTH had a similar prolonged effect on the reproductive function of female rats, which was manifested by changes in the physical and sensory-motor development of their offspring; reduced the level of anxiety and improved adaptation to the new environment.


Key words

neuropeptides, fragment 4-10 of adrenocorticotropic hormone, delta sleep inducing peptide, physical development offspring, sensory-motor development offspring, postnatal development, reproductive function of female, index of physical development, ind

Reference list

1. Estestvoznanie. Enciklopedicheskii slovar https://dic.academic.ru/contents.nsf/


natural_science/


2. Ribnikov, V.U. Peptidnaya regylyaciya fynkcii mozga / V.U. Ribnikov, N.G. Zakyckii. - S-Pb.: BRA «Foliant», 2000. - 40 s.


3. Shataeva, L.K. Peptidnaya samoregylyaciya jivih sistem (fakti i gipotezi) / L.K. Shataeva, V.H. Havinson, I.U. Ryadnova − SPb.: «Nayka», 2003. - 222 s.


4. Bolshaya rossiiskaya enciklopediya. / Naych.-red. sovet: U.S. Osipov (pred.) [i dr.]; Otv. red. S.L. Kravec. - T.22. - M.: «Bolshaya Rossiiskaya enciklopediya», 2013. - 767 s.


5. Ashmarin, I.P. Regylyatornie peptidi, fynkcionalno-neprerivnaya sovokypnost / I.P. Ashmarin, M.F. Obyhova // Biohimiya. − 1986. − T.51, ?4. − S.531-545.


6. Sewald, N. Peptides: Chemistry and biology / N. Sewald, H.-D. Jakubke. − Willey-VCH, 2002. - 543 p.


7. Homytov, A.E. Regylyatornie peptidi. Ychebno-metodicheskoe posobie / A.E. Homytov, K.A. Pyrsanov, Z.V. Perepeluk. - N. Novgorod: Izd-vo NNGY, 2014. - 73 s.


8. Gomazkov, O.A. Mozg i neiropeptidi: Spravochno-informacionnoe izdanie / O.A. Gomazkov / In-t biomed. himii RAMN. − M.: B.I., 1997. - 170 s.


9. Matsionis, A. Morphometric analysis of synaptic plasticity of sensorimotor cortex under neuropeptidal correction of hypo- and hyperoxic damages / A. Matsionis, I. Pavlov, G. Kuraev [et al] // International Journal of Developmental Neuroscience. - 1996. - Vol.14, ?51. - P.84.


10. Povilaititc, P. Morphological basis of delta-sleep inducing peptide antistressory action: ultrastructural changes of axospinous synapses / P. Povilaititc, A. Matsionis, I. Pavlov [et al.] // International Journal of Developmental Neuroscience. - 1996. - Vol.14, ?51. - P.85.


11. Hershkowitz, M. The effect of ACTH on rat brain synaptic plasma membrane lipid fluidity / M. Hershkowitz, H. Zwiers, W.H. Gispen // Biochim. Biophys. Acta. − 1982. − Vol.692, ?3. − P.495-497.


12. Ashmarin, I.P. Nootropnii analog adrenokortikotropina 4-10- Semaks (15-letnii opit razrabotki i izycheniya) / I.P. Ashmarin, V.N. Nezavibatko, N.F. Myasoedov [i dr.] // Jyrnal Visshaya nervnaya deyatelnost. - 1997. - T.47, Vip.3. - S.420-430.


13. Volkov, A.V. Rezyltati primeneniya regylyatornih peptidov pri reanimacii posle ostanovki serdca v eksperimente / A.V. Volkov, U.V. Zarjeckii, A.U. Postnov [i dr.] V kn.: Terminalnie sostoyaniya i postreanimacionnaya patologiya organizma: patofiziologiya, klinika, profilaktika i lechenie. - M.: In-t obshei reanimatologii RAMN, 1992. - S.69-76.


14 Shabanov, P.D. Peptidnie neiroprotektori / P.D. Shabanov // Farmakologiya − prakticheskomy zdravoohraneniu. − SPb., 2007. − S. 2-29.


15. Shustanova, T.A. Features of regulating delta sleep-inducing peptide by free radical processes in tissue and erythrocyte membranes in intact animals and under stress / T.A. Shustanova, T.I. Bondarenko, N.P. Miliutina [et al.] // Usp. Fiziol. Nauk. - 2003. - Vol.34, ?1. - P.31-44.


16. Graf, M.V. Delta-sleep-inducing peptide (DSIP): an update / M.V. Graf, A.J. Kastin // Peptides. - 1986. - Vol.7. - P.1165-1187.


17. Pravila laboratornoi praktiki. Prikaz Ministerstva zdravoohraneniya i socialnogo razvitiya Rossiiskoi Federacii ot 23 avgysta 2010 g. ? 708n g. Moskva. Zaregistrirovan v Minuste RF 13 oktyabrya 2010 g. Registracionnii ?18713.


18. Belyakova, N.A. Razvitie potomstva, novie podhodi k ocenke v eksperimentalnoi biologii i medicine / N.A. Belyakova, E.U. Bonitenko, A.V. Nosov // Medline. - 2020. - T 21. - S. 1115-1134.


19 Beili, N. Statisticheskie metodi v biologii / N. Beili - M.: «Mir», 1963. - 271 s.


20. Rebrova, O.U. Statisticheskii analiz medicinskih dannih. Primenenie paketa prikladnoi programmi STATISTICA / O.U. Rebrova. - M.: «Media Sfera», 2002 - 312 s.