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Vol. 21, Art. 75 (pp. 935-948)    |    2020       

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Indicators of the antioxidant system in the long-term period after acute mercury nitrate poisoning in the experiment

Federal State budgetary Educational Institution of Higher Education «St. Petersburg State University»
«Institute of Toxicology» of Federal Medico-Biological Agency of Russia

Brief summary

An important problem of modern medicine is the elucidation of the mechanisms of the formation of lesions in the remote period when exposed to mercury. The article presents experimental data on the state of the antioxidant system in erythrocytes of white outbred rats 1 and 3 months after acute poisoning with mercury nitrate at a half-lethal dose and pharmacological correction with unitiol. It was found that this form of intoxication is accompanied by pronounced changes in the state of the antioxidant defense system in the erythrocytes of poisoned animals (a decrease in the concentration of reduced glutathione, a decrease in the activity of superoxide dismutase and glutathione peroxidase, an increase in the concentration of lipid peroxidation products). The content of mercury in the blood of experimental animals remains elevated throughout the study period. The results obtained indicate the significant importance of impaired functioning of the antioxidant system in the implementation of the remote consequences of acute mercury poisoning. The introduction of unitiol eliminated the revealed imbalance of the antioxidant system due to the activation of its enzymatic link and a decrease in the activity of lipid peroxidation.


Key words

mercury nitrate, unitiol, glutathione, superoxide dismutase, glutathione peroxidase, malondialdehyde.

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