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Vol. 21, Art. 30 (pp. 366-376)    |    2020       

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Cardiotropic effect of sublethal and lethal concentrations of sodium nitrite on the functional activity of an isolated heart

Research Institute of Hygiene, Occupational Pathology and Human Ecology

Brief summary

On the model of an isolated rat heart, the cardiotropic effect of sodium nitrite was studied in the range of concentrations from 1×10-6 M to the maximum - 6,5×10-2 M, corresponding to the LD50 dose for the whole organism. It is shown that sodium nitrite causes dose-independent dilation of the coronary bed, starting from a concentration of 1×10-4 M in threshold concentrations (1×10-4 M), the vasoactive effect of sodium nitrite is mediated by NO-dependent mechanisms and can be stopped by a soluble guanylate cyclase inhibitor-methylene blue. In lethal concentrations corresponding to LD50, dilatation of the coronary bed is caused by an increase in the content of sodium ions. In high concentrations (6,5×10-2 M), multiples of LD50, sodium nitrite leads to the development of a negative chronotropic effect, the mechanism of which is not associated with the activation of soluble guanylate cyclase and hypernatremia.


Key words

sodium nitrite, isolated heart, vasodilation, bradycardia, cardiotoxicity

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