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Vol. 21, Art. 2 (pp. 11-22)    |    2020       

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Experimental model of combined radiation-chemical injury after exposure of x-ray radiation and intoxication by carbon monoxide

Military Medical Academy. CM. Kirova

Brief summary

In the article is presented the experimental model of combined radiation-chemical injury. Laboratory animals had been exposed of x-ray radiation and intoxication of carbon monoxide. The injury of laboratory animals was modeled exposure x-ray radiation in the dose range of LD30-90/30 and exposure of carbon monoxide (2100 ppm, 30 minutes). It was shown that the combined radiation-chemical injury was been more severe compared to the isolated exposure of these factors. It was characterized more several decreased of hematopoiesis, the more several leukopenia and increased mortality compare animals was exposure x-ray radiation. The model can be used for reproducing the main manifestation of combined radiation-chemical injury, studying the features of pathogenesis and estimation the effectiveness of the therapy.


Key words

Х-ray, radiation, carbon monoxide, intoxication, combined radiation injury, leukopenia, hemopoiesis.

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