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Vol. 19, Art. 62 (pp. 861-879)    |    2018       

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Obesity-related kidney disease: modern aspects of pathogenesis, diagnostics and treatment (review of the literature)

Salukhov V.V., Rudakov Yu.V., Shelukhin V.A., Kan E.A.

S.M. Kirov Military Medical Academy, Saint Petersburg, Russia

Brief summary

The review of the world literature devoted to the synthesis of modern aspects of epidemiology, pathogenesis, diagnosis and treatment of obesity-related kidney disease is presented. The problems of terminology and diagnosis of kidney damage in obesity are discussed. Genetic, hemodynamic and metabolic risk factors and molecular - cell mechanisms of damage to the major kidney compartments associated with obesity are presented. The results of experimental data obtained in a laboratory animal model and in cell culture, histological studies of autopsy material and nephrobiopaths of patients with obesity-related kidney disease are demonstrated. The main therapeutic strategies have been determined, taking into account current ideas about the pathophysiological mechanisms of the formation of chronic kidney disease associated with obesity.


Key words

оbesity, obesity-related kidney disease, glomerulopathy, hyperfiltration, chronic kidney disease.

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