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Vol. 19, Art. 51 (pp. 693-704)    |    2018       

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Preclinical screening of atherosclerosis in young age

Serdyukov D.Y.

S.M. Kirov Military Medical Academy, Saint Petersburg, Russia

Brief summary

Objective: to develop an algorithm for the early detection of atherosclerotic changes for example carotid arteries in the category of young men. Material and methods: at Department of Hospital Therapy Military Medical Academy was examined of 437 men. After an evaluation of intima-media complex thickness of the carotid arteries patients have been divided into 2 groups: 1st - 62 men with signs of initial atherosclerosis; 2nd - 375 men without changes of the vascular wall. All of the examined patients have been evaluated lipid, carbohydrate metabolism and functional indicators of liver. Results: The patients with initial atherosclerosis has identified a number of characteristics: high frequency of cardiovascular risk factors (arterial hypertension, abdominal obesity, physical inactivity), dyslipidemia and dysglycemia, as well as fatty liver. As result of the study have been proposed a mathematical prediction model of atherosclerosis from young men (age, the presence of violations of lipid and carbohydrate metabolism, and level of alanin aminotransferase) and survey scheme for men over 35 years for early detection of signs of atherosclerosis. Conclusion: debut of atherosclerosis in young age is associated with the combined influence of cardiovascular disease, fatty liver and metabolic disorders, which are implemented through the mechanisms of endothelial dysfunction and insulinoresistance.


Key words

initial atherosclerosis, dyslipidemia, early post-load hyperglycemia, young age men, ultrasound carotid examination, intima-media complex.

Reference list

1. Demograficheskii ejegodnik Rossii. 2017. Stat. sb. Rosstat. M.;2017:264.


2. Kardiovaskylyarnaya profilaktika: nacionalnie rekomendacii. M.; 2017:288.


3. Von Reutern G-M, Goertler M-W, Bornstein NM et al. Grading carotid stenosis using ultrasonic methods. Stroke. 2012;43:916-21.


4. Rosvall M, Janzona L, Berglundb G et al. Incidence of stroke is related to carotid IMT even in the absence of plaque. Atherosclerosis. 2005;179 (2):325-31.


5. Benjamin EJ, Blaha MJ, Chiuve SE et al. Heart Disease and Stroke Statistics?2017 Update A Report From the American Heart Association. Circulation. 2017:459.


6. Bianchi C, Miccoli R, Trombetta M et al. Elevated 1-hour postload plasma glucose levels identify subjects with normal glucose tolerance but impaired β-cell function, insulin resistance, and worse cardiovascular risk profile: the GENFIEV study. J. Clin. Endocrinol. Metab. 2013;98(5):2100-5.


7. Häring H-U. Novel phenotypes of prediabetes? Diabetologia. 2016;59:1806-18.


8. Myromceva GA, Koncevaya AV, Konstantinov VO i dr. Rasprostranennost faktorov riska neinfekcionnih zabolevanii v rossiiskoi popylyacii v 2012-2013 gg. Rezyltati issledovaniya ESSE-RF. Kardiovaskylyarnaya terapiya i profilaktika. 2014;13(6):4-11.


9. Ivashkin V.T. Rasprostranennost nealkogolnoi jirovoi bolezni pecheni y pacientov ambylatorno-poliklinicheskoi praktiki v Rossiiskoi Federacii: rezyltati issledovaniya DIREG 2. Rosc. jyrn. gastroenterologii, gepatologii, koloproktologii. 2015;6:1-41.


10. Kitade H Nonalcoholic fatty liver disease and insulin resistance: new insights and potential new treatments. Nutrients. 2017;9:2-13.


11. Farcaş AD, Vonica CL, Golea AC Nonalcoholic fatty liver disease, bulb carotid intima-media thickness and obesity phenotypes: results of a prospective observational study. Med. Ultrason. 2017;19(3):265-271.


12. Patil R, Sood GK Nonalcoholic fatty liver disease and cardiovascular risk. World J. Gastrointest. Pathophysiol. 2017;8(2):51-58.