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Vol. 19, Art. 45 (pp. 612-623)    |    2018       

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New opportunaties for early diagnosis of diabetic autonomic neuropathy

Zelenina T.A. ,1 Salukhov V.V. ,1 Zheleznyak S.G.,1 Volkova E.A.,2 Zemlyanoy A.B.3

1S.M. Kirov Military Medical Academy, Saint Petersburg, Russia
2I.I. Mechnikov North-Western State Medical University, Saint Petersburg, Russia
3N.I. Pirogov National Medical and Surgical Center, Saint Petersburg, Russia

Brief summary

Purpose. Diabetic autonomic neuropathy is the reason for early morbidity and mortality on diabetic patients. We estimated the potential of High-frequency Ultrasonic Dopplerography for early diagnosis of cardiac autonomic neuropathy. Design/methodology/approach. 52 diabetic patients with sensorimotor neuropathy were examined. Cardiac autonomic neuropathy was detected using several cardiovascular autonomic reflex tests as a gold standard of diagnosis. Microvascular blood flow of finger skin was valuated at rest as well as in functional tests: with cold impact and occlusion (cuff). Findings. The cold test had great relevance for diagnosis of autonomic neuropathy (sensitivity 100%, specificity 77.4%). The functional tests performing by High-frequency Ultrasonic Dopplerography were offered for early diagnosis of diabetic cardiac autonomic neuropathy. Originality/value. High-frequency Ultrasonic Dopplerography allowed to separate of cardiac autonomic neuropathy stages. This study is necessary to continue for revealing of all method possibilities.


Key words

diabetes mellitus, cardiac autonomic neuropathy, High-Frequency Ultrasonic Dopplerography.

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