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Vol. 16, Art. 97 (pp. 1099-1105)    |    2015       

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Clinical and laboratory diagnosis of autoimmune endometritis

N.B. Shanina, O.L. Molchanov, A.A. Shmidt, A.M. Ivanov

Military Medical Academy named after SM Kirov

Brief summary

The article deals with the result of study systemic immunity indications of 51 patients with autoimmune endometritis, chronic endometritis and the absence of endometritis, according to the immunohistochemical method. With the presence of autoimmune endometritis, immunological response is characterized with a decrease of cytotoxic lymphocytes (CD3+CD8+), the decrease of T-killer cells (CD3+CD16+CD56+), the increase of immunoregulation index (CD3+CD4+/CD3+CD8+), the increase of Ig A and IFN-γ in the blood, which confirms the autoimmune type of inflammation. Differential diagnosis of chronic inflammation in the endometrium is needed by assessing the local immune status by immunohistochemical method and by assessing the overall immune status to apply the pathogenetically substantiated program of immunotherapy.


Key words

autoimmune endometritis, chronic endometritis, immunohistochemical method.

Reference list

1. Danysevich I.N. Osnovnie markeri dizregylyacii immynnoi, endokrinnoi sistem i svobodnoradikalnogo okisleniya lipidov y jenshin s reprodyktivnimi narysheniyami, associirovannimi s hronicheskim vospaleniem endometriya: Dis. ? d-ra med. nayk / I.N. Danysevich. - Irkytsk, 2014. - S. 58-59.


2. Kyznecova A.V. Hronicheskii endometrit / A.V. Kyznecova // Arhiv patologii. - 2000. - N3. - S.48-52.


3. Mihnina E.A. Morfofynkcionalnoe sostoyanie endometriya y jenshin s besplodiem i nevinashivaniem beremennosti: Dis. ? d-ra med. nayk / E.A. Mihnina. - SPb., 2009. - S. 9-218.


4. Optimizaciya patogeneticheskoi terapii y jenshin s privichnim nevinashivaniem beremennosti 1 trimestra, s ychetom immynomorfologicheskih osobennostei endometriya/ V.V. Gnipova, V.M. Sidelnikova, A.A. Agadjanova [i dr.] // Materiali V Rossiiskogo foryma "Mate i ditya". - M.,2003. - S. 51-52.


5. Patent RF 2003104391/15 Sposob diagnostiki hronicheskogo endometrita i haraktera vospaleniya / E.A. Mihnina, V.N. El-linidi, N.M. Kalinina [i dr.]. - Zayavl. 02.10.2003; opybl. 09.10.2004.


6. Syhih, G.T. Immynomorfologicheskie osobennosti endometriya y jenshin s hronicheskim endometritom / G.T. Syhih, A.V. Shyrshalina, V.N. Veryasov // Bul. eksp. biol. i med. - 2006. - T. 141, N 1. - S. 113-115.


7. Ellinidi V.N., Kalinina N.M. Immynomorfologiya endometriya. Lechenie besplodiya: nereshennie problemi. - Saratov, 2001. - S. 158-162.


8. Spencer T.E. Conceptus signals for establishment and maintenance of pregnancy / T.E. Spencer, R.C. Burghardt, G.A. Johnson [et al] // Anim Reprod Sci. - 2004. - Vol.82-83. - P. 537-550.


9. Dosiou, C. Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectives. / S. Dosiou, L.C. Giudice // Endocr.Rev. - 2004. - Vol.26,Nl. - P. 44-62.


10. Kerr-Leighton, J.A. Chronic endometritis plasma cells in the hysterectomy specimens of HIV-infected women: A retrospective analysis / J.A. Kerr-Leighton // Infect. Dis. Obstet. Gynecol. - 1998. - Vol. 6, N 4. - P. 186-190.