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Vol. 16, Art. 70 (pp. 759-765)    |    2015       

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The efficiency of mexidol and diazepam in the тreatment of anxiety-phobic state induced by non-competitive gaba- antagonists

Kulazhin O.A., Kolosova N.A.

27 Research center of the Ministry of Defense of the Russian Federation, Moscow

Brief summary

In the present report discusses experimental data characterizing dose-dependent features of the formation of anxiety-phobic states in intoxication non-competitive GABA -antagonists in experiments on rodents. The differences anxiogenic action bicycloheptane and tetramethylenedisulfotetramine explained by their inhibition of chlorine-ionophore GABAA- receptors and the effect on the density of benzodiazepine receptors in the brain structures. Discusses the features of the anxiolytic action of diazepam and mexidol in conditions of acute poisoning by blockers of GABA-dependent chlorine ion channels.


Key words

anxiolytics, GABA-antagonist, acute poisoning, anxiety-phobic state.

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