Опубликовать статью

Информационное партнерство

Инфоресурсы

Контакты

«

Vol. 16, Art. 43 (pp. 456-474)    |    2015       

»

Development and methodological approaches to personalization valuation toxic load on the body

Mulik A.B., Shatyr Y.A., Postnova M.V.

Volgograd State University

Brief summary

Theoretically, the expediency of personalization valuation toxic load on the body. Provides a systematic approach to the opportunities in the real experimental and practical activities to quantify and qualitatively typologize functional status of human and laboratory animals by the level of general non-specific reactivity. Characterized the effects of toxic manifestations of standard loads in experimental animals with different levels of general non-specific reactivity.


Key words

valuation of toxic loads, toxicity, experimental animals, standardization of experimental animals, the level of total non-specific reactivity.

Reference list

1. Chypis, V.N. Primenenie v ekologicheskih issledovaniyah metodov biotestirovaniya na kyltyrah kletok cheloveka i jivotnih / V.N. Chypis, L.L. Jyravleva, D.E. Ivanov // Teoreticheskaya i prikladnaya ekologiya. - 2008.-№ 4.- S.71-76.


2. Barratt, M.D., Rodford R.A. The computational prediction of toxicity // Current Opinion in Chemical Biology. —2001. —V. 5, N 4. —P. 383-388.


3. Kovalenko, V.N. Alternativnie metodi v doklinicheskom izychenii toksichnosti lekarstvennih sredstv /V.N. Kovalenko // Sovremennie problemi toksikologii.- 2002. - № 4.- S.14-18.


4. Novochadov, V.V. Patomorfologiya hronicheskogo endotoksikoza: rezyltati izycheniya i problemi // Astrahanskii med. jyrnal. – 2007. – T.2, №2. – S. 134-135.


5. Lyjnikov, E.A. Pediatricheskaya i klinicheskaya toksikologiya / E.A. Lyjnikov, Syhodolova G.N. - Rostov-na-Dony: Feniks, 2013. - 253 s.


6. Nikols, Dj.G., Ot neirona k mozgy / Dj.G. Nikolls, A.R. Martin, B.Dj. Vallas, P.A._Fyks – M.: YRSS, 2010. – 672 s.


7. Mulik, A.B. Standardization of laboratory animals. Features of lipid metabolism depending on the general nonspecific reactivity level / A.B. Mulik, N.G. Tikhonov, V.V. Novochadov // Baltic Journal of Laboratory Animal Science.- 1998.-N 8.- P.238-241.


8. Mulik, A.B. General nonspecific reactinity level as the integrate criterion of the standardization of Biological models/ A.B. Mulik // Baltic J. Lab.Anim. Sci.- 2000.V.10.-P. 86-93.


9. Mylik, A.B. Biometricheskaya harakteristika bolevoi chyvstvitelnosti organizma / A.B. Mylik, U.A. Shatir, M.V. Postnova // Sensornie sistemi.- 2013.- T. 27, № 1.- S.60-67.


10. Mylik, A.B. Yniversalnii metod ocenki yrovnya obshei nespecificheskoi reaktivnosti organizma cheloveka i tradicionnih vidov laboratornih jivotnih / A.B. Mylik // Vestnik volgogradskogo gosydarstvennogo yniversiteta. Seriya 11: Estestvennie nayki.-2012.- №2.- S.11-15.


11. Mylik, A.B. Yniversalnii metod opredeleniya poroga bolevoi chyvstvitelnosti y tradicionnih vidov laboratornih jivotnih / A.B. Mylik, U.A. Shatir // Rossiiskii jyrnal boli.- 2012.- №2.- S.7-10.


12. Novikov, D.A. Statisticheskie metodi v eksperimentalnoi biologii i medicine / D.A. Novikov, V.V. Novochadov. – Volgograd: Izd-vo VolGMY, 2005. – 84 s.