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Vol. 16, Art. 31 (pp. 335-343)    |    2015       

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Gc-ms and hplc-ms analysis of biological samples from rats exposed by aliphatic c6-c10 hydrocarbons

Ukolov A.I. *, Migalovskaya E.D., Radilov A.S.

Research Institute of Hygiene, Occupational Pathology and Human Ecology Federal State Unitary Enterprise, Federal Medical Biological Agency of Russia

Brief summary

A metabolites of hexane, heptane and octane was determined in plasma samples, brain and liver of rats exposed to aliphatic hydrocarbons. Hexanone-2, heptanone-2 was determined in the liver and brain, hexanol-1 was found only in the brain. In the plasma samples was detected hexanone-2, heptanone-2, 1-octanol, 2,5-hexanedione. Dimethylpyrrolnorleucine was determined in blood by HPLC-MS. Metabolites of C9-C10 hydrocarbons have not been identified.


Key words

hydrocarbons, hexane, heptane, octane, HPLC-MS, GC-MS, blood plasma, brain, liver.

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