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Vol. 16, Art. 109 (pp. 1250-1264)    |    2015       

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Three-day and five-day decitabine regimen comparative efficacy in myelodysplastic syndrome.

Dudina G.A.,1 Golenkov A.K., Mitina T.A.2

1 Moscow Clinical Scientific and Practical Center;
2 Moscow Regional Clinica Research Institut name of MF Vladimir

Brief summary

The article presents the results of a single-center retrospective clinical study of decitabine efficacy (DNA hypermethylation inhibitor) in 52 patients with MDS using 3-day and 5-day treatment regimens in the context of practical public health. The patients therapy regimen depending analysis showed that the overall survival in patients with low and intermediate MDS risk was 34 months and 30 months in a three-day and a five-day therapy regimen respectively. Whereas in patients with a higher progression risk it was 28 and 12 months, respectively. The overall survival in general for the two groups also differed: 29 months vs 20 months in the 3-day and 5 days regimen respectively. Thus, the probability of the decitabine cumulative dose effect on the survival rates improvement was confirmed. Statistical analysis was performed by Statistica 6.0.


Key words

myelodysplastic syndrome, DNA hypermethylation, hypomethylating therapy, decitabine, cumulative dose of the drug.

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