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Vol. 15, Art. 31 (pp. 366-380)    |    2014       

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Peculiarities of regulatory mechanisms of compensation of diffusive liver lesion brought about by toxic impact of carbon tetrachloride and рolyhexamethyleneguanidine hydrochloride

Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Ekaterinburg;
SEI HPE Ural Medical University (UGMU) Russian Ministry of Health

Brief summary

The outcome of an experiment, executed on animals, enables to comparatively assess the pancreas injure caused by two toxic substances - carbon tetrachloride (CCl4) and рoly hexamethyleneguanidine hydrochloride (PGMG). It has been established that unlike in case of direct hepatotrophic effect of (CCl4), the toxic effect of (PGMG) on hepatocytes has a secondary nature, conditioned by progressing tissue hypoxia, at the background of blood circulation failure in the organ.


Key words

toxic lesion, hepatocyte, alteration, inflammation, proliferation.

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