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Vol. 15, Art. 22 (pp. 238-249)    |    2014       

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Factors of circadian dynamics individualization of the liver metabolic activity in guinea pigs under acute toxic effects

Novochadov V.V., Shatyr Y.A. , Kudryavtseva G.A., Mulik A.B.

Volgograd State University

Brief summary

Under conditions of acute toxic exposure (lipopolysaccharide S. Thyphimurium) is defined the specificity of circadian dynamics of the liver metabolic activity in guinea pigs with different levels of general non-specific reactivity of the organism. Characterized expression of lipid’s growth and products of their peroxidation, as well as the degree of reduction of intermediate metabolism’s enzyme activity in the liver after the introduction of bacterial lipopolysaccharide at different times of day.


Key words

toxic effects, liver metabolism, the level of general non-specific reactivity, circadian biorhythms, individualization of homeostasis.

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