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Vol. 14, Art. 71 (pp. 900-916)    |    2013       

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Present status of lung cancer screening

Kostitsin K.A.

«N.N. Petrov Research Institute of Oncology», Ministry of Healthcare of the Russia and
St. Petersburg Clinical Research Centre of special types of medical care (Oncology)

Brief summary

This paper summarizes the published data on the effectiveness of lung cancer screening programs and provides preliminary data on thefirst phase of the Russian trial with 324 participants. Paper outlines the necessity of randomized controlled trials, with the primary goal to estimate the mortality from the disease, to make evidence-based conclusions. It is shown that so far only one study (NLST) has achieved a relative reduction in mortality from lung cancer by 20.0% (overall reduction - 6.7%). On the basis of own data it is demonstrated that the implementation of screening should be done with thorough quality control - only 64.7% of CT scans fully satisfy the objectives and only 75.9% of the patients met the inclusion criteria. However, the promising results were shown with the enrollment of participants, and the screening efficiency of the first stage was confirmed by detection of lung lesions in 37.9% of the participants, of whom 19,8% (n=64) had lesions 10 mm or larger. A follow-up algorithm is proposed to further optimize lung cancer diagnostics.


Key words

lung cancer, screening, low-dose computed tomography, quality assurance, lung nodules.

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