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Vol. 14, Art. 62 (pp. 773-788)    |    2013       

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Qualitative and quantitative analysis of diffusion-weighted imaging of bone marrow under normal conditions at different ages

D.G. Pavlov1, I.A.Trofimenko1,2, I.V.Boykov2

St. Petersburg State City Hospital № 40,
2 - Military Medical Academy

Brief summary

To study the qualitative and quantitative features of normal bone marrow at diffusion- weighted imaging 75 healthy individuals were examined. Scanning of the axial skeleton was performed at a system with a magnetic field strength of 1.5 Tesla . Normal bone marrow showed variable signal at diffusion- weighted images with signal intensity correlated with patient age: those under 46 years usually showed hyperintensive signal of bone marrow at diffusion-weighted images with high b value. Mean apparent diffusion coefficient in the bone marrow of healthy individuals was 0,45±0,11x10-3 mm2/s without significant differences in various anatomical regions. The values of the apparent diffusion coefficient turned to be inversely proportional to the age of patients with significant reduction in the older age groups.


Key words

bone marrow, magnetic resonance imaging, diffusion-weighted images, apparent diffusion coefficient, normal condition

Reference list

1. Bruhanov, A.V. Magnitno-rezonansnaya tomografiya v osteologii / A.V. Bruhanov, A.U. Vasilev. – M.: Medicina, 2006. - 200 s.


2. Pronin, I.N. Diffyzionno-vzveshennie izobrajeniya v issledovanii opyholei golovnogo mozga i peritymoralnogo oteka / I.N. Pronin, V.N. Kornienko, L.M. Fadeeva i dr. // Voprosi neirohiryrgii, - 2000. - №3. – C. 14-17.


3. Raizer, M. Lychevaya diagnostika. Kostno-mishechnaya sistema / M. Raizer, A. Bayr-Melnik, K. Glaser per. s angl. / M.: MEDpress-inform, 2011. - 382 s.


4. Antoch, G. Whole-body dual-modality PET/CT and whole-body MRI for tumor staging in oncology / G. Antoch, F.M. Vogt, L.S. Freudenberg et al. / JAMA. – 2003. – Vol.290, №24. - P.3199-3206.


5. Ashkan, A. Principles and Applications of Diffusion-weighted Imaging in Cancer Detection, Staging, Treatment and Follow-up / A. Ashkan et al. // Radiographics. – 2013. - №31. – P. 1773-1791.


6. Baert, A.L. Diffusion of the body / A.L. Baert. - Berlin Heidelberg.: Springer-Verlag, 2010. - 298 p.


7. Charles-Edwards, E.M. Diffusion-weighted magnetic resonance imaging and its application to cancer / E.M. Charles-Edwards et al. // Cancer Imaging. – 2006. - №6. – P. 135–143.


8. Chen, W. Whole-body diffusion-weighted imaging vs. FDG-PET for the detection of non-small-cell lung cancer: how do they measure up? / W.Chen, W. Jian, H.T. Li, et al. // Magn. Reson. Imaging. – 2010. Vol.28. – P.613–620.


9. Chen, Y.B. Staging of uterine cervical carcinoma: whole-body diffusion-weighted magnetic resonance imaging / Y.B. Chen, C.M. Hu, G.L. Chen et al. // J. Abdom. Imaging. – 2011. – Vol.36. - P.619–626.


10. Daldrup-Link, H.E. Whole-body MR imaging for detection of bone metastases in children and young adults: comparison with skeletal scintigraphy and FDG PET / H.E. Daldrup-Link , C. Franzius , T.M. Link et al. // AJR. – 2001. Vol.177, №1. – P.229-236.


11. Feydy, A. Diffusion-weighted MRI and ADC measurement of tumoral bone marrow / A. Feydy, J.L. Drape, C. Argaud. // Proc. Intl. Soc. Mag. Reson. Med. - 2001. – Vol. 9. – 2117 p.


12. Gokalp, G. Evaluation of vertebral bone marrow fat content by chemical-shift MRI in osteopor / G. Gokalp, F.S. Mutlu, Z. Yazici et al. // Skeletal Radiol. – 2011. – Vol.40. – P.577–585.


13. Kul, S. Contribution of diffusion-weighted imaging to dynamic contrast-enhanced MRI in the characterization of  breast tumors / S. Kul , A. Cansu, E. Alhan , et al. // AJR Am J Roentgenol. – 2011. - Jan 196, №1. 210-217.


14. Reischauer, C. Bone metastases from prostate cancer: assessing treatment response by using diffusion-weighted imaging and functional diffusion maps—initial observations / C. Reischauer, J.M. Froehlich, D.M. Koh, et al. // Radiology. – 2010. - №257. - P. 523–531.


15. Schmidt, G.P. Whole-body magnetic resonance imaging and positron emission tomography-computed tomography in oncology / G.P. Schmidt, et al. // Top Magn Reson Imaging. - 2007. - №18. – P. 193–202.


16. Vande Berg, B.C. Classification and detection of bone marrow lesions with magnetic resonance imaging / B.C. Vande Berg, J. Malgem, F.E. Lecouvet, et al. // Skeletal Radiol. -  1998. № 27. – P. 529–545.


17. Vande Berg, B.C. Magnetic resonance imaging of normal bone marrow / B.C. Vande Berg, J. Malgem, F.E. Lecouvet, et al. // Eur Radiol. – 1998. №8. – P. 1327–1334.