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Vol. 14, Art. 47 (pp. 541-551)    |    2013       

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Impact of HLA class I and class II alleles matching of the donor and recipient on the risk of acute and chronic graft-versus-host disease after allogeneic unrelated hematopoietic stem cell transplantations

Kuzmich E.V., Makarenko O.A., Alynskiy A.A., Timofeeva N.P., Ivanova N.E., Bondarenko S.N., Zubarovskaya L.S., Afanasyev B.V.

First Pavlov State Medical University of St. Petersburg, Raisa Gorbacheva Memorial Institute for Pediatric Oncology, Hematology and Transplantation

Brief summary

In the present study we analyzed the results of 390 unrelated allogeneic hematopoietic stem cell transplantations which were performed at Raisa Gorbacheva Memorial Institute for Pediatric Oncology, Hematology and Transplantation between January 2001 and December 2012. The aim of the study is to analyze the impact of HLA class I and class II alleles matching of the donor and recipient on the risk of acute and chronic graft-versus-host disease (GVHD). The risk of grades III-IV acute GVHD was influenced by the number of mismatched alleles, individual class I and class II loci disparities of the donor and recipient. An increased risk of grades III-IV acute GVHD was associated with mismatched alleles of HLA-DRB1, HLA-C, HLA-B loci for 9 of 10 allele-matched pairs. Hazards of chronic GVHD in the group with a 10/10 allele-matched transplant and in the group with a single I class allele and single II class allele mismatches were equal in the analyzed cohort.


Key words

unrelated allogeneic hematopoietic stem cell transplantation, graft-versus-host disease, HLA class I and class II alleles of the donor and recipient.

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