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Федеральное государственное бюджетное учреждение науки
Институт теоретической и экспериментальной биофизики
Российской академии наук


ООО "ИЦ КОМКОН"

Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

ISSN 1999-6314


Клиническая медицина » Хирургия • Трансфузиология

Том: 14
Статья: « 68 »
Страницы:. 861-879
Опубликована в журнале: 12 сентября 2013 г.
English version

Антифосфолипидный синдром

Колосков А.В., 1,2,3 Филиппова О.И., 1,2 Столица А.А., 3 Бессмельцев С.С. 4

ГБОУ ВПО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России, кафедра трансфузиологии
ГБУЗ «Городская больница № 26»
ФГБУ «Федеральный центр сердца крови и эндокринологии имени В.А. Алмазова»
Федеральный специализированный перинатальный центр
ФГБУ «Российский НИИ гематологии и трансфузиологии ФМБА России»


Резюме
Антифосфолипидный синдром представляет собой системное аутоиммунное заболевание, связанное с тромбозами сосудов и/или повторными эпизодами гибели плода в присутствии устойчиво повышенного уровня антифосфолипидных антител. Основной антигенной мишенью для этих антител был идентифицирован β2-гликопротеин I, который выступает посредником для связывания антифосфолипидных антител с клетками – мишенями, включая эндотелиальные клетки, моноциты, тромбоциты и клетки трофобласта, что приводит протромботическим и провоспалительным изменениям которые, в конечном счете, могут привести к развитию тромбоза и/или гибели плода. С момента создания международной предварительной классификации и критериев диагностики антифосфолипидного синдрома в 1999 году был выполнен значительный объем работы в области фундаментальных исследований, позволивший получить новую информацию. Клинические критерии антифосфолипидного синдрома были пересмотрены в Сиднее в 2006 году. Само по себе присутствие антифосфолипидных антител не означает развитие у пациента антифосфолипидного синдрома. Для диагностики антифосфолипидного синдрома требуется комбинация, по меньшей мере, одного клинического и одного лабораторного критерия. Критерии Сиднея не рекомендуют использовать термин «вторичный антифосфолипидный синдром». Выполненные исследования не смогли найти различия в клинических последствиях действия антифосфолипидных антител у пациентов с первичным и вторичным антифосфолипидным синдромом.


Ключевые слова
антифосфолипидный синдром, β2-гликопротеин I, клинические критерии


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