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Vol. 13, Art. 75 (pp. 895-899)    |    2012       

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Analysis of mutation of mitochondrial gene heteroplasmy C5178A NADH dehydrogenase subunit 2 in aortic intima damaged gomogenatah

Kosogorova S.A.(3), Sazonova М.А.(1,2,3), Chicheva M.M. (1,2), Mitrofanov K.Yu.(1,2), Zhelankin A.V.(1,2), Korobov G.A.(1,2), Sobenin I.A.(1,2,3)
1 Institute of General Pathology and Pathophysiology RAMS , Moscow, Russian Federation;
2 Russian Cardiology Research and Production Complex, Moscow, Russian Federation;
3 Institute for Atherosclerosis Research, Skolkovo Innovative Centre; Moscow, Russian Federation.

Brief summary

An analysis of heteroplasmy level was made in DNA samples with mutation of mitochondrial genome C5178A NADH dehydrogenase subunit 2 in DNA samples isolated from total homogenates of normal and atherosclerotic intimal 10 aortas. It was revealed that the heteroplasmy level of the mutant allele С5178A in homogenates of atherosclerotic lesions is significantly higher compared to total homogenates of normal intima.


Key words

mitochondrial mutationstotal intimal homogenatesatherosclerosisheteroplasmymutation

Reference list

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