Опубликовать статью

Информационное партнерство

Инфоресурсы

Контакты

«

Vol. 13, Art. 72 (pp. 861-870)    |    2012       

»

Use of 99mТс MIBI SPECT in examination of patients with non-small cell lung cancer

Beinusov D.S.

N.N. Petrov Research Institute of Oncology

Brief summary

The article presents the main results of a prospective clinical study of diagnostic value of single photon emission computed tomography with 99mTc MIBI (SPECT) X-ray computed tomography (CT), and combination of these methods in staging 83 patients with non-small cell lung cancer. The study demonstrated a significant increase in sensitivity (from 88 to 94%), using a combination of CT-SPECT in the detection of regional spread of NSCLC. In addition found that the combination of CT-SPECT in patients with no radiographic evidence of atelectasis and obstructive pneumonia (49 cases) can increase specificity of 88%.


Key words

lung cancer, staging, SPECT, CT

Reference list

1. Kanaev S.V., Novikov S.N., Beinysov D.S., Girshovich M.M., Levchenko E.V., Barchyk A.S., Semenov I.I., Jykova L.A., Macko D.E. Opit ispolzovaniya odnovremennoi dvyhizotopnoi emissionnoi komputernoi tomografii s Ts99m-tehnetrilom i Ga67- citratom pri obsledovanii bolnih nemelkokletochnim rakom legkogo // Voprosi onkologii. – 2012. – T.58. - №3. – S. 346-351


2. Levchenko E.V. Problemi stadirovaniya i ocenki effektivnosti lecheniya NMRL. // Prakticheskaya onkologiya. – 2006. – T.7. – №3. – S. 138-144.


3. Trahtenberg A.H., Chissov V.I. Rak legkogo. – M.: GEOTAR-Media, 2009. – 660 s.


4. Tulyandin S.A., Nosov D.A., Perevodchikova N.I. Minimalnie klinicheskie rekomendacii Evropeiskogo Obshestva Medicinskoi Onkologii (ESMO) // M.: Izdatelskaya gryppa RONC im. N.N. Blohina, redakciya rysskogo perevoda. - 2010. – S. 156


5. Alongi F., Ragusa P., Montemaggi P., Bona C.M. Combining independent studies of diagnostic fluorodeoxyglucose positron-emission tomography and computed tomography in mediastinal lymph node staging for non-small cell lung cancer // Tumori. – 2006. Vol. 92, № 4. – P. 327-333.


6. Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics // CA: a cancer journal for clinicians. – 2011. Vol. 61, №2. – P. 134.


7. de Langen A.J., Raijmakers P., Riphagen I., Paul M.A., Hoekstra O.S. The size of mediastinal lymph nodes and its relation with metastatic involvement: a meta-analysis // European journal of cardio-thoracic surgery. – 2006. Vol. 29, №1. – P. 26-29.


8. Mountain C.F., Dresler C.M. Regional lymph node classification for lung cancer staging // Chest. – 1997. Vol. 111, № 6. – P. 1718-1723


9. Nikoletic K., Lucic S., Peter A., Kolarov V., Zeravica R., Srbovan D. Lung 99mTc-MIBI scintigraphy: impact on diagnosis of solitary pulmonary nodule // Bosnian journal of basic medical sciences. – 2011. Vol. 11, № 3. – P. 174-179.


10. Santini M., Fiorello A., Mansi L., Rambaldi P.F., Vicidomini G., Busiello L., Messina G., Nargi P. The role of technetium-99m hexakis-2-methoxyisobutyl isonitrile in the detection of neoplastic lung lesions // European journal of cardio-thoracic surgery. – 2009. Vol. 35, № 2. – P. 325-331.


11. Schillaci O. Single-photon emission computed tomography/computed tomography in lung cancer and malignant lymphoma // Seminars in nuclear medicine. – 2006. Vol. 36, № 4. – P. 275-285.


12. Shah A.A., Berry M.F., Tzao C., Gandhi M., Worni M., Pietrobon R., D'Amico T.A. Induction chemoradiation is not superior to induction chemotherapy alone in stage IIIA lung cancer // The Annals of thoracic surgery. – 2012. Vol. 93, № 6. P. – 1807-1812.


13. Silvestri G.A., Gould M.K., Margolis M.L., Tanoue L.T., McCrory D., Toloza E., Detterbeck F. Noninvasive staging of non-small cell lung cancer: ACCP evidencedbased clinical practice guidelines (2nd edition) // Chest. – 2007. Vol. 132, (3 Suppl.). – P. 178S-201S.


14. Spanu A., Schillaci O., Pirina P., Arru A., Madeddu G., Chessa F., Marongiu P., Solinas M.E., Madeddu G. 99mTc-tetrofosmin SPECT in solitary pulmonary nodule evaluation // Oncology reports. – 2006. Vol. 16, № 4. – P. 763-769.


15. Staples C., Müller N., Miller R., Evans K., Nelems B. Mediastinal nodes in bronchogenic carcinoma: comparison between CT and mediastinoscopy // Radiology. – 1988. – Vol. 167, № 2. – R. 367-372.


16. De Wever W., Ceyssens S., Mortelmans L., Stroobants S., Marchal G., Bogaert J., Verschakelen J.A. Additional value of PET-CT in the staging of lung cancer: comparison with CT alone, PET alone and visual correlation of PET and CT // European radiology. – 2007. Vol. 17, № 1. – P. 23-32.


17. White P., Adams H., Crane M., Butchart E. Preoperative staging of carcinoma of the bronchus: can computed tomographic scanning reliably identify stage III tumours? // Thorax. – 1994. – Vol. 49(10). – P. 951-957.