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Vol. 13, Art. 70 (pp. 841-852)    |    2012       

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Platelets dysfunction as the cause of hemorrhagic diathesis in women

Saparkina M.V. 1, Koloskov A.V. 1,2, Philippova O.I. 2, Stolitsa A.A. 1

1Almazov federal heart, blood and endocrinology centre
2City Hospital № 26, St.Petersburg, Russia

Brief summary

The concept of "hemorrhagic diathesis" unites a group of different diseases and syndromes, the hallmark of which is pathological bleeding (spontaneous and provoked), which may be due to different pathogenetic mechanisms. For women, this disease is a more pressing problem than for men, due to their physiological characteristics (availability of monthly menstrual blood loss and the function of reproduction, which may be associated with profuse blood loss). The most common manifestation of bleeding disorders in women are menorrhagia, as women with bleeding disorders susceptible to chronic anemia with iron deficiency, more active bleeding with endometriosis, bleeding in benign conditions such as fibroids, endometrial hyperplasia and polyps, and hemorrhagic ovarian cysts. Also available are a variety of obstetric complications, including spontaneous abortion, obstetric hemorrhage, especially postpartum. Most bleeding manifestations are not unique to women with bleeding disorders, they are just more serious and more evident. In this review highlight a fairly common condition that leads to the symptoms of abnormal bleeding in women - thrombocytopathies.


Key words

hemorrhagic diathesis, thrombocytopathies, platelets dysfunction, menorrhagia

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