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Vol. 13, Art. 45 (pp. 556-565)    |    2012       

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Effect of exogenous melatonin and retinoic acid on the genes expression in the body of planarians Schmidtea mediterranea

Ermakova O.N., Ermakov A.M.

The Institute of Theoretical and Experimental Biophysics of Russia Academy of Sciences 142290, Russia

Brief summary

On the example of the unique biological model - freshwater planarian flatworms shown that exogenous melatonin and retinoic acid can affect the expression of genes in the body of these animals. It was found that the introduction of retinoic acid in the body by feeding planarians significantly increases their biological activity, especially 9-cis-retinoic acid. In general, demonstrated that melatonin and retinoic acid have morphogenetic effect in primitive animals on the expression level of genes.


Key words

planarians, stem cells, regeneration, morphogenesis, gene expression.

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