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Vol. 13, Art. 17 (pp. 207-217)    |    2012       

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The PROGINS allele of the progesterone receptor (PGR) gene is associated with the increased risk of breast cancer in Western Siberian region of Russia

Pechkovskiy E. V.1; Weiner A. S.1,2; Boyarskikh U. A.1; Biltueva Ju. A.1; Selezneva I. A.3; Sinkina T. V.3; Lazarev A. F.3; Petrova V. D.3; Filipenko M. L.1

1 Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, 630090

2 Novosibirsk State University, Novosibirsk, 630090

3 Altai Branch of Russian N.N. Blokhin Cancer Research Centre, Barnaul, 656049

Brief summary

Breast cancer (BC) is the most incident cancer among women. Genetic polymorphism of progesterone receptor may be involved in the etiology of BC. In the present study we aimed to investigate the association of polymorphism rs1042838 (PROGINS allele) of PGR gene with the risk of BC in the West Siberian Region of Russia. We analyzed the case (644 BC women) and the control (466 women) groups. Allele T (OR = 1.30; p = 0.02) and genotype Т/Т (OR = 2.19; p = 0.03) were associated with the increased risk of BC. After stratification of the case group according to PGR expression status, we revealed an association only in the subgroup of patients with low level of PGR expression (for allele T: OR = 1.52; p = 0.006; for genotype Т/Т: OR = 2.67; p = 0.03).


Key words

breast cancer, progesterone receptor, PROGINS allele, association, Russian population

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