Military Medical Academy named after S.M. Kirov,
Academic Lebedev str., 6, Saint Petersburg, 194044, Russia
Brief summary
Modern drug discovery and development is the interdisciplinary process. Today, the process of drug discovery has been revolutionized due to the advances in bioinformatics. Efficient technologies such as combinatorial chemistry, high throughput screening (HTS), virtual screening, de novo design and structure-based drug design contribute greatly to drug discovery. This paper presents a review of current advances and novel approaches in experimental and computational drug discovery and design.
Key words
prediction, drug discovery, pharmacokinetics, virtual screening, QSAR
1. Albert A. Izbiratelnaya toksichnost. Fiziko-himicheskie osnovi terapii. V 2-h tomah / Per. s angl. M.A. Dympis, M.B. Ganinoi pod red. prof. V.A. Filova / M.: Medicina. 1989. - 400 s.
3. King R. Himicheskie prilojeniya topologii i teorii grafov. – M.: Mir. – 1987. – 560 s.
4. Palm V.A. Osnovi kolichestvennoi teorii organicheskih reakcii. — 2-e, per. i dop.. — L.: Himiya, 1977. — 360 s.
5. Raevskii O.A. Deskriptori vodorodnoi svyazi v komputernom molekylyarnom dizaine. Ros. him. j. (J. Ros. him. ob-va im. D.I.Mendeleeva) (2006). L (2): 97-107.
6. Raevskii O.A. Deskriptori molekylyarnoi stryktyri v komputernom dizaine biologicheski aktivnih veshestv // Yspehi himii. – 1999. – T. 68, № 6. – S. 555- 575.