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Vol. 12, Art. 26 (pp. 311-325)    |    mart 2011       

№ гос. регистрации: 0421100002\\0026

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Autonomy of growth foci of adenomyosis: immunogistohomicheskie particular expression of markers

E.A. Kogan¹, N.V.Nizyaeva², T.A. Demura¹, L.S. Ejova¹, A.L. Unanyan³

1- ФГУ «Научный Центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова» Минздравсоцразвития РФ (директор– акад. РАМН, проф. Г.Т.Сухих), 117997, Москва.
2- Кафедра патологической анатомии лечебного фак-та (зав. кафедрой–проф. В.С.Пауков) ГОУ ВПО Первого МГМУ им.И.М. Сеченова Минздравсоцразвития РФ, 119991, Москва
3- Кафедра акушерства и гинекологии №1 лечебного фак-та (зав.- Член –корр. РАМН, д.м.н., проф. И.С.Сидорова) ГОУ ВПО Первого МГМУ им. И.М. Сеченова Минздравсоцразвития РФ, 119991, Москва

Brief summary

The aim of our study was to investigate mechanisms оf autonomous growth of adenomyotic foci in combination with endometrial adenocarcinoma (EA) of the uterine corpus. The study was performed on surgical material of excised uteri from 70 patients of the age 35 – 78 with adenomyosis and with combination of adenomyosis and EA. Immunohistochemical study was performed on serial paraffin slides. Monoclonal and polyclonal antibodies to ApoCas, Ki-7, MMP-2, MMP-9, TIMP-1, COX-2, EGFR, and VEGF were used as primary antibodies. We found that increase and progression of adenomyotic foci may be due to systemic or local hyperestrogenism and under local stimulatiom with growth factors, such as COX-2, VEGF, EGF. The local action of these cytokins may result in development of adenomyotic foci autonomous growth. Hyperplastic epithelium with atypia in adenomyotic foci may give origin to саrcinoma of the uterine corpus.


Key words

adenomyosis, endometrioid adenocarcinoma СОХ-2, EGFR, MMP-2, MMP-9, VEGF

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