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Vol. 12, Art. 25 (pp. 301-310)    |    mart 2011       

№ гос. регистрации: 0421100002\0025

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Activity of lipid peroxidation in the lung remodeling influenced by long-time intermittent exposure of nitrogen dioxide

Kozlova M.Y., Lebedeva E.S., Preobrazhenskaya T.N., Grebenjuk A.N.

Medical Military Academy
194044, Sankt-Petersburg, Lebedeva, 6

Brief summary

The intensity of lipid peroxidation (LPO), antioxidant status and morphological reconstruction of lung tissue were evaluated in Wistar rats during prolonged (15, 30 and 60 days) intermittent (1,5 h/day) exposure of nitrogen dioxide in concentration (30-40 mg/m3), which had no acute toxic effect on lung structures. With the elongation nitrogen dioxide exposure the intensity of LPO increased: at 60 day content of malondialdehyde in lung tissue was 142 % higher than in control (intact rats). Lung tissue reserves of reduced glutathione and ascorbic acid were twice declining. Activities of glutathione depending enzymes decreased. Consequence of destructive processes initiated by excessive production of free radicals was the formation chronic inflammatory bronchopulmonary process with signs of lung tissue remodeling (emphysema and focal fibrosis) at 60 day nitrogen dioxide exposure. The high intensity of LPO, insufficient antioxidant function and structural changes in lung tissue persisted for six months after cessation of nitrogen dioxide exposure.


Key words

lipid peroxidation, nitrogen dioxide, chronic inflammation, lung.

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